A5058206623- Cardiac, Anesthesia and Surgical Outcomes
- Platelet Disorders and Treatments
- Kruppel-like factors research
- Enhanced Recovery After Surgery
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
- Acute Kidney Injury Research
- Abdominal Surgery and Complications
- Machine Learning in Healthcare
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Blood transfusion and management
- Anesthesia and Pain Management
- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Dialysis and Renal Disease Management
- Diagnosis and Treatment of Venous Diseases
- Bat Biology and Ecology Studies
- Health and Wellbeing Research
- Pancreatic function and diabetes
- Periodontal Regeneration and Treatments
- Developmental Biology and Gene Regulation
- Non-Invasive Vital Sign Monitoring
St George’s University Hospitals NHS Foundation Trust
2023-2024
University of Cambridge
2018-2023
National Health Service
2020-2022
Wellcome/MRC Cambridge Stem Cell Institute
2020-2022
NHS Blood and Transplant
2022
Medical Research Council
2020-2021
Addenbrooke's Hospital
2018
Abstract Aims Patients with chronic kidney disease (CKD) or heart failure (HF) are disproportionally affected by frailty, an independent predictor of morbidity. The prevalence frailty and its impact on quality life (QoL) in a unique population patients both CKD HF (CKD‐HF) is unclear. aim this study was to investigate the association between QoL CKD‐HF. Methods results were identified from tertiary care cardiorenal clinic. Eligible had CKD‐HF stable estimated glomerular filtration rate...
Abstract The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience the forward programming (FoP) human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects complex challenges bring this technology bedside. We first identify clinical-grade hPSC lines that generate MKs efficiently. design a bespoke media maximize both maturity improve platelet output. Crucially, transition lentiviral-based FoP hPSCs...
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood count. Proplatelet formation releases into bloodstream beads-on-a-string preplatelets, which undergo fission mature platelets. For first time, we show that preplatelet is third, tightly regulated, critical akin cytokinesis regulates We deficiency in cytokine...
Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family stress-sensing kinases trigger integrated stress response (ISR), which has pro-survival and developmental consequences. Bone morphogenetic proteins (BMPs) regulate multiple processes in organisms from insects mammals. Here we show Drosophila that GCN2 antagonises BMP signalling through direct effects on translation indirectly via transcription factor crc (dATF4). Expression constitutively...
Background Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability. Methods We conducted prospective, single-centre study of prone COVID-19 non-COVID-19 pneumonia. The primary outcome was change peripheral oxygenation versus supine position. Secondary outcomes assessed effects...
among the priorities to address which could be supported by One Health strategies.A OHCF has been developed with a multidisciplinary effort facilitate detection of threats at human-animal-environment interface, assess risks for pandemic, support evaluation possible impacts and provide input prevention.The aims guiding relevant national sectors towards harmonised context driven OH strategies in prevention preparedness identifies priority actions Governance, Data collection analysis Capacity...
Abstract Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family stress sensing kinases trigger integrated response (ISR), which has pro-survival and developmental consequences. Mutations ISR kinase GCN2 have been implicated in development pulmonary arterial hypertension, disorder known associated with defects BMP signaling, but how signaling might interact is unknown. Here we show Drosophila that antagonises through direct effects on...