A5014538136- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Virus-based gene therapy research
- Advanced Sensor and Energy Harvesting Materials
- Immunotherapy and Immune Responses
- Graphene research and applications
- Lanthanide and Transition Metal Complexes
- Conducting polymers and applications
- Electrospun Nanofibers in Biomedical Applications
- Sulfur Compounds in Biology
- Polymer Nanocomposite Synthesis and Irradiation
Tongji University
2011-2013
Southwest Jiaotong University
2008-2011
Abstract In biomedical applications, polyethylene glycol (PEG) functionalization has been a major approach to modify nanocarriers such as nano‐graphene oxide for particular biological requirements. However, incorporation of PEG shell poses significant diffusion barrier that adversely affects the release loaded drugs. This study addresses this critical issue by employing redox‐responsive detachment mechanism. A PEGylated (NGO‐SS‐mPEG) with detachable is developed can rapidly an encapsulated...
Hybrid mesoporous silica nanoparticles (MSNs), which were synthesized using the co-condensation method and engineered with unique redox-responsive gatekeepers, developed for studying glutathione-mediated controlled release. These hybrid constitute a core that can accommodate guests (i.e., drug, dye) PEG shell be connected via disulfide-linker. Interestingly, selectively detached from inner at tumor-relevant glutathione (GSH) levels facilitate release of encapsulated manner. The structure...
A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
Nuclear localized signals (NLS) capable of recognition by nuclear transport proteins can aid the translocation payloads. In this report, NLS peptide PKKKRKV (PV7, one primary peptides) was introduced into GO-PEI (10 kDa)/DNA binary complexes to engineer a nuclei gene delivery system, based on electrostatic and hydrogen-bonded interactions. To assess functional mechanism peptides in PV7 via three different routes, including post-addition after formation GO-PEI/DNA binary, simultaneous...
Abstract Because of its unique chemical and physical properties, graphene oxide (GO) has attracted a large number researchers to explore biomedical applications in the past few years. Here, we synthesized novel multifunctional nanocomposite based on GO systemically investigated for vitro hepatocarcinoma diagnosis treatment. This named GO‐PEG‐FA/Gd/DOX was obtained as following procedures: gadolinium‐diethylenetriamine‐pentaacetic acid‐poly(diallyl dimethylammonium) chloride (Gd‐DTPA‐PDDA)...
Abstract A multi‐component nanosystem based on graphene and comprising individual cyclodextrins at its surface is assembled, creating hybrid structures enabling new important functionalities: optical imaging, drug storage, cell targeting for medical diagnosis treatment. These nanohybrids are part of a universal system interchangeable units, capable mutilple functionalities. The components, made β‐cyclodextrin molecules, the “hosts” functional which may be used as imaging agents, anti‐cancer...
The aim of the present work was to design a targeting polysaccharide-based cationic polymer for gene delivery. PEI is one most widely studied polymers in terms delivery, yet its applications are limited by inherent drawbacks. To address these drawbacks, grafted low-molecular-weight branched polyethylenimine (PEI) (1800 Da and 800 Da) with low cytotoxicity ligand were integrated into polymeric system based on biodegradable biocompatible polysaccharide dextran, afford highly efficient delivery...