A5023270797- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- COVID-19 Clinical Research Studies
- Occupational exposure and asthma
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Inhalation and Respiratory Drug Delivery
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Inflammatory Myopathies and Dermatomyositis
- Pleural and Pulmonary Diseases
- Polyomavirus and related diseases
- Respiratory and Cough-Related Research
- Multiple Sclerosis Research Studies
- Heart Rate Variability and Autonomic Control
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
University of British Columbia
2008-2025
Vancouver General Hospital
2022-2025
University of Calgary
2025
University of Toronto
2020-2025
St. Paul's Hospital
1999-2025
St. Paul's Hospital
2019-2025
Université de Montréal
2025
Murdoch Children's Research Institute
2024
University of Lausanne
2023
University of Basel
2023
<b>Over 75% of patients admitted to hospital with COVID-19 have abnormal patient-reported outcome measures 3 months after symptom onset, a third reporting at least moderate impairment in major dimensions quality life</b>https://bit.ly/32QMMgw
The long-term respiratory morbidity of COVID-19 remains unclear. We describe the clinical, radiological and pulmonary function abnormalities that persist in previously hospitalised patients assessed 12 weeks after symptom onset, identify clinical predictors outcomes. At least one variable was abnormal 58% 88% had imaging on chest CT. There strong association between days oxygen supplementation during acute phase both DLCO-% (diffusion capacity lung for carbon monoxide) predicted total CT...
Section:ChooseTop of pageAbstract <<IntroductionMethodsHistorical PerspectiveEpidemiologyEtiologiesClinical Manifestations a...Lung FunctionImaging FeaturesPathology FeaturesOutcome and ComplicationsPathogenesis Putative...Terminology Definitio...Is CPFE a Syndrome?ManagementClinical Trial Perspectiv...Relevance for the...Research PrioritiesConclusionsReferencesCITING ARTICLES
Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain.Patients were enrolled from the Canadian Registry for Pulmonary Fibrosis between 2015 2020. was defined as a relative forced vital capacity (FVC) decline ≥10%, death, transplantation or any two of: FVC ≥5% <10%, worsening respiratory symptoms fibrosis on computed tomography...
Extent of fibrosis, defined by the amount honeycombing and traction bronchiectasis, was consistently associated with death or lung transplant across all interstitial disease subtypes in a dose-dependent fashion.
Background Long-term oxygen therapy (LTOT) improves survival in patients with chronic severe resting hypoxaemia, but effects on hospitalisation are unknown. This study evaluated the potential impact of starting LTOT acute exacerbation and hospital burden obstructive pulmonary disease (COPD), interstitial lung (ILD) hypertension (PH). Methods Longitudinal analysis consecutive population-based Swedish DISCOVERY cohort who started between 2000 2018 a follow-up duration≥3 months. Total...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the leading reason for hospitalization in Canada and a significant financial burden on hospital resources. Identifying factors that influence time patient spends readmission rates will allow better use scarce resources.To determine length stay (LOS) patients with AECOPD an inner-city hospital.Using Providence Health Records, retrospective review admitted to St Paul's Hospital (Vancouver, British Columbia) during winter...
Fatigue is a common symptom in hospitalized and non-hospitalized patients recovering from COVID-19, but no fatigue measurement scales or questions have been validated these populations. The objective of this study was to perform validity assessments the severity scale (FSS) two single-item screening (SISQs) for COVID-19.We examined ≥ 28 days after their first SARS-CoV-2 infection who were acute illness, as well referred persistent symptoms. Patients completed questionnaires through 1 4 Post...
The pathophysiology, evolution, and associated outcomes of post-COVID dyspnea remain unknown. aim this study was to determine the prevalence, severity, predictors 12 months following hospitalization for COVID-19, describe respiratory, cardiac, patient-reported in patients with dyspnea.We enrolled a prospective cohort all adult admitted 2 academic hospitals Vancouver, Canada PCR-confirmed SARS-CoV-2 during first wave COVID between March June 2020. Dyspnea measured 3, 6, after initial symptom...
Abstract Objectives Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, immunosuppression response. Methods Patients with CTD-ILD had high-resolution chest CT (HRCT) reviewed by expert radiologists blinded clinical data for overall pattern [usual interstitial pneumonia (UIP); non-specific (NSIP); organizing (OP); fibrotic hypersensitivity pneumonitis (fHP); other]. Transplant-free...
Rationale The European Quality of Life 5-Dimensions 5-Levels questionnaire (EQ-5D-5L) is a multidimensional patient-reported that supports calculation quality-adjusted life-years. Our objectives were to demonstrate feasibility use and calculate the minimum important difference (MID) EQ-5D-5L its associated visual analogue scale (EQ-VAS) in patients with fibrotic interstitial lung disease (ILD). Methods Patients who completed identified from prospective multicentre CAnadian REgistry for...
Objectives We sought to 1) identify long COVID phenotypes based on patient reported outcome measures (PROMs) and 2) determine whether the were associated with quality of life (QoL) and/or lung function. Methods This was a longitudinal cohort study hospitalized non-hospitalized patients from March 2020 January 2022 that conducted across 4 Post-COVID Recovery Clinics in British Columbia, Canada. Latent class analysis used using baseline PROMs (fatigue, dyspnea, cough, anxiety, depression,...
Accurate separation of idiopathic pulmonary fibrosis from fibrotic (chronic) hypersensitivity pneumonitis is crucial to patient management, but frequently a difficult problem. Our objective was identify pathologic variables that help make this separation. Clinical, radiological, and data were re-reviewed for 23 patients with interstitial lung disease biopsy suggesting or pneumonitis. Clinical features, high-resolution computed tomography, surgical biopsies each examined independently using...
The aim of this study was to compare respiratory and patient-reported outcome measures (PROMs) between 3 6 months after symptom onset identify features that predict these changes.This a consecutive prospective cohort 73 patients who were hospitalised with coronavirus disease 2019 (COVID-19). We evaluated the changes in pulmonary function tests PROMs then investigated associations outcomes (change diffusing capacity lung for carbon monoxide (DLCO), dyspnoea quality life (QoL)) clinical...
Background Little is known about generalisability of randomised controlled trials (RCTs) for idiopathic pulmonary fibrosis (IPF). We evaluated eligibility criteria phase III IPF RCTs to determine their representativeness in clinical registries, and calculated forced vital capacity (FVC) changes according criteria. Methods Common used >60% were identified from a literature search applied patients with prospective Australian Canadian registries. Additional pre-specified 6-min walk distance...
Abstract Background and objective Inhalational exposures are a known cause of interstitial lung disease (ILD), but little is understood about their prevalence across ILD subtypes relationship with pulmonary function survival. Methods Patients fibrotic were identified from the multicentre Canadian Registry for Pulmonary Fibrosis. completed questionnaires regarding ILD‐related occupational environmental exposures. The between outcomes baseline age, gender, family history, survival was analysed...