A5078925351- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Scientific Computing and Data Management
- Biomedical Text Mining and Ontologies
- Semantic Web and Ontologies
- Distributed and Parallel Computing Systems
- Blockchain Technology Applications and Security
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Computational Drug Discovery Methods
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Distributed systems and fault tolerance
- vaccines and immunoinformatics approaches
- Cloud Data Security Solutions
- CRISPR and Genetic Engineering
- Service-Oriented Architecture and Web Services
Open Targets
2016-2020
European Bioinformatics Institute
2016-2020
Wellcome Trust
2017
Aristotle University of Thessaloniki
2015-2016
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies. scope the has also expanded targeted exome arrays with 1000 new associations added these technologies. As September 2018, contains 5687 comprising 71673 variant-trait from 3567 publications. New content includes 284 full P-value summary statistics datasets...
Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction conformation from a wide range of cell types tissues to make robust connections between GWAS-associated loci, variants likely causal genes. This enables systematic identification prioritisation genes across all published trait-associated loci. In this paper, we describe the...
We have designed and developed a data integration visualization platform that provides evidence about the association of known potential drug targets with diseases. The is to support identification prioritization biological for follow-up. Each target linked disease using integrated genome-wide from broad range sources. either target-centric workflow identify diseases may be associated specific target, or disease-centric disease. Users can easily transition between these target- workflows....
The availability of user-friendly software to annotate biological datasets and experimental details is becoming essential in data management practices, both local storage systems public databases. Ontology Lookup Service (OLS, http://www.ebi.ac.uk/ols) a popular centralized service query, browse navigate biomedical ontologies controlled vocabularies. Recently, the OLS framework has been completely redeveloped (version 3.0), including enhancements model, like added support for Web Language...
Modes Of Operation The 4 modes of operation are presented below: 1. MCL clusters the protein query and database Results In era Big Data in Life Sciences, efficient process analysis vast amounts sequence We have implemented proposed framework using a number scripts suitable for Unix sequences. clustering criteria is BLAST output (identity or e-value), based on preference user 2. Phylogenetic profiles each sequence, where genomes into consideration ones whose proteins form 3. sequences...