A5051195556- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Adenosine and Purinergic Signaling
- Forensic Toxicology and Drug Analysis
- Calcium signaling and nucleotide metabolism
- Bioactive Compounds and Antitumor Agents
- Peptidase Inhibition and Analysis
- Quinazolinone synthesis and applications
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
Universitat Jaume I
2016-2022
Dipeptidyl nitroalkenes are potent reversible inhibitors of cysteine proteases. Inhibitor 11 resulted to be the most one with Ki values 0.49 and 0.44 nM against rhodesain cruzain, respectively. According enzymatic dilution dialysis experiments, as well computational NMR studies, dipeptidyl tightly binding covalent inhibitors.
Since the outbreak of COVID-19, one strategies used to search for new drugs has been find inhibitors main protease (Mpro) virus SARS-CoV-2. Initially, previously reported related proteases like SARS-CoV and MERS-CoV were tested. Then a huge effort done by scientific community design, synthesize test small molecules acting as inactivators SARS-CoV-2 Mpro. From structure view, these compounds can be classified into two groups: corresponds modified peptides displaying an adequate sequence high...
Abstract A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization the double bond at side chain happened during synthesis. The resulting analogues derived from both isomeric compounds entered cells suggesting wide applicability ABA‐NBD conjugates probes to study ABA mechanism action. functional properties were tested in vitro, measuring TNFα expression and nitrite...
Aldehydes are easily transformed into vicinal diamines and piperazines through a one-pot procedure including Darzens reaction treatment with an amine or diamine then reducing agent. Additionally, quinoxalines can be accessed by 1,2-benzenediamine under oxidative conditions. These transformations simple methods for the preparation of synthetically interesting monosubstituted diamines, piperazines, quinoxalines.