A5006028425- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- SARS-CoV-2 and COVID-19 Research
- Crystallography and molecular interactions
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- COVID-19 Clinical Research Studies
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Ruminant Nutrition and Digestive Physiology
- Membrane Separation Technologies
- Supramolecular Self-Assembly in Materials
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Long-Term Effects of COVID-19
- Mesoporous Materials and Catalysis
- Animal Diversity and Health Studies
- Nanoparticle-Based Drug Delivery
- Advancements in Battery Materials
- Fuel Cells and Related Materials
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 detection and testing
- Endometrial and Cervical Cancer Treatments
- COVID-19 Impact on Reproduction
- Parasitic Diseases Research and Treatment
Desert Research Center
2014-2025
King Abdulaziz City for Science and Technology
2014-2024
Northwestern University
2015
Porous metal–organic frameworks (MOFs) have been studied in the context of a wide variety applications, particularly relation to molecular storage and separation sciences. Recently, we reported green, renewable framework material composed γ-cyclodextrin (γ-CD) alkali metal salts—namely, CD-MOF. This porous has shown facilitate mixtures alkylaromatic compounds, including BTEX mixture (benzene, toluene, ethylbenzene, regioisomers xylene), into their pure components, both liquid gas phases, an...
Although ibuprofen is one of the most widely used nonsteroidal anti-inflammatory drugs (NSAIDs), it exhibits poor solubility in aqueous and physiological environments as a free acid. In order to improve its oral bioavailability rate uptake, extensive research into development new formulations has been undertaken, including use excipients well salts, such lysinate ibuprofen, sodium salt. The ultimate goals these studies are reduce time required for maximum uptake this period directly...
Molecular triangles containing naphthalenediimide redox-active units are employed as promising active materials for organic lithium-ion batteries. In addition to exceptional low-rate performance, a capacity of 71.1 mAh g−1 is maintained at 10 C after 300 cycles. The performance these compounds exists in contrast control monomer, which lacks the same shape-persistent structure. As service our authors and readers, this journal provides supporting information supplied by authors. Such peer...
Middle East Respiratory Syndrome Coronavirus-(MERS-CoV) infection is an evolving worldwide health crisis. The early diagnosis and management of the disease remains a major challenge. This study designed to discuss epidemiology, pathogenesis clinical appearances MERS-CoV infections.We conducted broad search English-language literature in "PubMed" "Medline" "Web knowledge", "EMBASE" "Google Scholar" World Health Organization-WHO" using key words "Middle Syndrome", "MERS", "MERS-CoV"...
Metal–organic frameworks (MOFs) are known to facilitate energy-efficient separations of important industrial chemical feedstocks. Here, we report how a class green MOFs—namely CD-MOFs—exhibits high shape selectivity toward aromatic hydrocarbons. CD-MOFs, which consist an extended porous network γ-cyclodextrins (γ-CDs) and alkali metal cations, can separate wide range benzenoid compounds as result their relative orientation packing within the transverse channels formed from linking (γ-CD)6...
Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are being deployed to suppress dengue transmission. However, there challenges in applying this technology extreme environments. We introduced two strains into Ae . from Saudi Arabia for a release program the hot coastal city of Jeddah. reduced infection and dissemination virus (DENV2) Arabian showed complete maternal transmission cytoplasmic incompatibility. egg hatch under range environmental conditions,...
Precise control of molecular assembly is a challenging goal facing supramolecular chemists. Herein, we report the highly specific range nanotubes from enantiomeric triangular naphthalenediimide-based macrocycles (RRRRRR)- and (SSSSSS)-NDI-Δ class similar solvents, namely, 1,2-dihalo-ethanes -ethenes (DXEs). Three kinds are formed columnar stacking NDI-Δ units with 60° mutual rotation angle as result cooperative [C–H···O] interactions, directing interactions [X···X]-bonded DXE chains inside...
Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in presence porcine liver esterase. The DOX loaded ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
Organic charge transfer cocrystals are inexpensive, modular, and solution-processable materials that able, in some instances, to exhibit properties such as optical nonlinearity, (semi)conductivity, ferroelectricity, magnetism. Although the of these have been investigated for decades, principal challenge researchers face currently is devise an efficient approach which allows growth high-quality crystalline materials, anticipation a host different technological applications. The research...
We report the synthesis of a series homologous oligoviologens in which different numbers 4,4'-bipyridinium (BIPY(2+)) subunits are linked by p-xylylene bridges, as prelude to investigating how their radical cationic forms self-assemble both solution and solid state. The strong radical-radical interactions between BIPY(2+) units-namely, BIPY(•+)-in these induce intra- or intermolecular folding homologues. UV/Vis/NIR spectroscopic studies DFT quantum mechanics indicate that shorter is...
Pseudomonas aeruginosa is a significant human pathogen, it possesses almost all of the known antimicrobial resistance mechanisms. Quorum sensing (QS) an intercellular communication system that orchestrates bacterial virulence and its targeting effective approach to diminish pathogenesis. Repurposing drugs advantageous strategy, in this study we aimed repurpose anti-diabetic sitagliptin, metformin vildagliptin as anti-QS P. aeruginosa. The effects sub-inhibitory concentrations tested on...
Multidrug resistant (MDR) methicillin-resistant
A strategy for creating foldameric oligorotaxanes composed of only positively charged components is reported. Threadlike components-namely oligoviologens-in which different numbers 4,4'-bipyridinium (BIPY(2+)) subunits are linked by p-xylylene bridges, shown to be capable being threaded cyclobis(paraquat-p-phenylene) (CBPQT(4+)) rings following the introduction radical-pairing interactions under reducing conditions. UV/vis/NIR spectroscopic and electrochemical investigations suggest that...
Herpes labialis, caused by herpes simplex virus type 1, is usually characterized painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against labialis but suffer from poor oral bioavailability. This study aimed combine the benefits of PV and lavender oil (LO), which exhibits anesthetic activity, in form a self-nanoemulsifying drug delivery system (SNEDDS) for treatment labialis. Toward this purpose, LO (oil), Labrasol:Labrafil M1944 CS ratio 6:4 (surfactant...
Bacterial infections have a significant impact on human health; they can cause severe morbidity and mortality, particularly in susceptible populations. Epidemiological surveillance is critical tool for monitoring the population's health facilitate prevention control of infectious disease outbreaks. Knowing burden bacterial communicable diseases an initial core step toward public goals.
A sugar and pH dual-responsive controlled release system, which is highly specific towards molecular stimuli, has been developed based on the binding between catechol boronic acid a platform of mesoporous silica nanoparticles (MSNs). By grafting phenylboronic stalks onto surface, catechol-containing β-cyclodextrins can be attached to orifices MSNs' nanopores through formation boronate esters block access nanopores. These are stable enough prevent cargo molecules from escaping. The...
Two potential radical promoted molecular lassos were synthesized, and their different behaviour under redox stimuli shows how the molecular-level properties of analogous compounds can be affected drastically by subtle structural differences.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an evolving global health crisis. Despite recent efforts, there are numerous notable gaps in the understanding of MERS-CoV seasonal diversity. We aimed at investigating occurrence coronavirus outbreaks.We obtained data on prevalence and infection from World Health Organization (WHO) for all MERS cases reported various countries their allied ministries. also recorded research documents published scientific journals during period...
The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses nanometer-sized cavity are described. host–guest properties the can be tuned modulated allosterically, where association heterotropic effector at periphery molecule serves to modulate its affinity for globular, electron-rich guest resides within cavity. This stimuli-responsive behavior was observed in both solution phase crystalline solid state, reversed with high fidelity by sequestration molecule.