A5010474437- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Muscle Physiology and Disorders
- Hereditary Neurological Disorders
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Neurological diseases and metabolism
- Advanced Proteomics Techniques and Applications
- Porphyrin Metabolism and Disorders
- Peroxisome Proliferator-Activated Receptors
University of Milan
2020-2021
The commitment of mesenchymal stem cells to preadipocytes is stimulated by hormonal induction. Preadipocytes induced differentiate repress protein synthesis, remodel their cytoskeleton, and increase mitochondrial function support anabolic pathways. These changes enable differentiation into mature adipocytes. Our understanding the factors that coordinately regulate early events adipocyte remains incomplete. Here, using multipronged approaches, we have identified zinc finger CCCH-type...
COASY protein-associated neurodegeneration (CoPAN) is a rare but devastating genetic autosomal recessive disorder of inborn error CoA metabolism, which shares with pantothenate kinase-associated (PKAN) similar features, such as dystonia, parkinsonian traits, cognitive impairment, axonal neuropathy, and brain iron accumulation. These two disorders are part the big group neurodegenerations accumulation (NBIA) for no effective treatment available at moment. To date, lack mammalian model, fully...