A5056937237- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Evolution and Genetic Dynamics
- Identification and Quantification in Food
- Animal Ecology and Behavior Studies
University of Lausanne
2021-2024
SIB Swiss Institute of Bioinformatics
2022-2024
Abstract Genomic measures of inbreeding based on identical‐by‐descent (IBD) segments are increasingly used to measure and mostly estimated SNP arrays whole‐genome sequencing (WGS) data. However, some softwares recurrently for their estimation assume that genomic positions which have not been genotyped nonvariant. This might be true WGS data, but reduced representations can lead spurious IBD estimation. In this project, we simulated the outputs WGS, two different sizes RAD‐sequencing three...
Measuring inbreeding and its consequences on fitness is central for many areas in biology including human genetics the conservation of endangered species. However, there no consensus best method, neither quantification itself nor model to estimate effect specific traits. We simulated traits based genomes from a large pedigree empirical whole-genome sequences data populations with various sizes structures (from 1,000 Genomes project). compare ability coefficients ( <mml:math...
Abstract Homologous recombination is a meiotic process that generates diversity along the genome and interacts with all evolutionary forces. Despite its importance, studies of landscapes are lacking due to methodological limitations limited data. Frequently used approaches include linkage mapping based on familial data provides sex-specific broad-scale estimates realized inferences population LD reveal more fine scale resolution landscape, albeit dependent effective size selective forces...
The study of insular populations was key in the development evolutionary theory. successful colonisation an island depends on geographic context, and specific characteristics organism island, but also stochastic processes. As a result, apparently identical islands may harbour with contrasting histories. Here, we use whole genome sequences 65 barn owls to investigate patterns inbreeding genetic diversity eastern Mediterranean Sea. We focus Crete Cyprus, similar size, climate distance...
Abstract Homologous recombination is a meiotic process that generates diversity along the genome and interacts with all evolutionary forces. Despite its importance, studies of landscapes are lacking due to methodological limitations dearth appropriate data. Linkage mapping based on familial data gives unbiased sex-specific broad-scale estimates while linkage disequilibrium (LD) inference population provides finer resolution albeit depending effective size acting selective In this study, we...
<title>Abstract</title> An important aspect of assessing endangered levels and managing conservation is the study inbreeding status, identifying its origin as well mutation load in wild populations. In this study, we used 502 barn owls from continental island populations across Europe. addition to comparing determined whether due non-random mating or high co-ancestry within population. We show that islands have higher than populations, mainly small effective population sizes rather recent...
A key aspect of assessing the risk extinction/extirpation for a particular wild species or population is status inbreeding, but origin inbreeding and current mutational load are also two crucial factors to consider when determining survival probability population. In this study, we used samples from 502 barn owls continental island populations across Europe, with aim quantifying comparing level between differing demographic histories. addition status, determined whether due non-random mating...
ABSTRACT Runs of homozygosity (ROHs) are proxy for genomic Identical-by-Descent segments and increasingly used to measure individual inbreeding. ROHs analyses mostly carried out on SNPs-arrays whole-genome-sequencing data. Softwares recurrently their detection usually assume that positions which have not been genotyped non-variant. This might be true data, but reduced representations can lead spurious detection. We simulated the outputs whole-genome-sequencing, two SNP-arrays RAD-sequencing...
Abstract Measuring inbreeding as well its consequences on fitness is central for many areas in biology including human genetics and the conservation of endangered species. However, there no consensus most appropriate method, neither quantification itself nor model to estimate effect specific traits. In this project, we simulated traits based genomes from a large pedigree empirical whole-genome sequences data populations with various sizes structure (from 1,000 Genomes project). We compare...
Abstract The study of insular populations was key in the development evolutionary theory. successful colonisation an island depends on geographic context, and specific characteristics organism island, but also stochastic processes. As a result, apparently identical islands may harbour with contrasting histories. Here, we use whole genome sequences 65 barn owls to investigate patterns inbreeding genetic diversity eastern Mediterranean Sea. We focus Crete Cyprus, similar size, climate distance...