A5074010544- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Genetic and Kidney Cyst Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Polyomavirus and related diseases
- Neuroblastoma Research and Treatments
- Cytomegalovirus and herpesvirus research
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Nutrition and Health in Aging
- Viral-associated cancers and disorders
- Gallbladder and Bile Duct Disorders
- Abdominal Trauma and Injuries
- Hepatitis C virus research
- Pediatric Hepatobiliary Diseases and Treatments
University of Kentucky HealthCare
2007-2024
University of Kentucky
2015-2024
Markey Cancer Center
2015-2024
University of Alabama at Birmingham
2022
University of Kent
2021
Mansoura University
2018
Cleveland Clinic
2016-2017
Symbiosis International University
2015
Albert B. Chandler Hospital
2015
Symbiosis Group
2015
<h3>Objective</h3>To determine outcomes in patients undergoing liver transplantation (LT) for metastatic neuroendocrine tumors (NETs).<h3>Design</h3>Retrospective analysis.<h3>Setting</h3>University of Kentucky Medical Center.<h3>Patients</h3>Patients LT performed NET metastases from October 1, 1988, through January 31, 2008, were analyzed using the United Network Organ Sharing database.<h3>Main Outcome Measure</h3>Patient survival.<h3>Results</h3>During study period, 87 280 LTs performed....
Sarcopenia is the most common complication of cirrhosis and adversely affects quality life outcomes before, during, after liver transplantation. We studied predictors sarcopenia sarcopenic obesity in patients with undergoing transplant (LT) evaluation.A retrospective analysis 207 adult cirrhotic that underwent LT from January 2008 to December 2013 was performed at our institution.Two hundred seven were evaluated, 68% male a mean age 54 ± 8 years. The etiology alcoholic disease (38.6%),...
Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 hepatocellular carcinomas (HCC), and a significant number these have mutations β-catenin gene. Therefore, effective inhibition this could provide novel method to treat HCC. The purposed study was determine whether FH535, which previously shown block pathway, inhibit activation target genes proliferation Liver Cancer Stem Cells (LCSC) HCC cell lines. Using responsive reporter genes, our data indicates that FH535 can...
Abstract Tremor is a common side effect of tacrolimus correlated with peak‐dose drug concentration. LCPT , novel, once‐daily, extended‐release formulation tacrolimus, has reduced C max comparable AUC exposure, requiring ~30% dose reduction vs. immediate‐release tacrolimus. In this p hase 3b study, kidney transplant recipients ( KTR ) on stable and reported clinically significant tremor were offered switch to . pre‐ seven d post‐conversion was evaluated by independent, blinded movement...
Alcoholic liver disease (ALD) is a common indication for transplantation worldwide. This study identifies factors predicting posttransplant recidivism.Clinical and laboratory data were reviewed. Uni- multivariate analyses survival relapse to alcohol illicit drugs performed.Between July 1995 November 2007, 387 patients underwent at our institution. Of these, 147 (38%) found have ALD. Five (3.4%) excluded because of perioperative mortality. Overall was 96.2%, 89.6%, 84.4% 1, 3, 5 years,...
To investigate independent contributions of obesity, diabetes, and smoking to resource utilization in patients following liver resection.Despite being highly resource-intensive, resections are performed with increasing frequency. This study evaluates how potentially modifiable factors affect measures after hepatectomy.The American College Surgeons' National Surgical Quality Improvement Program (ACS NSQIP) public-use database was queried for undergoing resection. Resource variables were...
Autophagy targets cellular components for lysosomal-dependent degradation in which the products of may be recycled protein synthesis and utilized energy production. also plays a critical role cell homeostasis regulation many physiological pathological processes prompts this investigation new agents to effect abnormal autophagy hepatocellular carcinoma (HCC). 2,5-Dichloro-N-(2-methyl-4-nitrophenyl) benzenesulfonamide (FH535) is synthetic inhibitor Wnt/β-catenin pathway that exhibits...
Patient outcome and the development of major intra-abdominal postoperative complications following removal cavernous hemangiomas liver are affected by methods resection.Case-control study.Hepatobiliary surgery transplantation unit in a tertiary care referral medical center.Between December 1, 1987, 1997, 28 patients underwent surgical hemangioma either hepatic resection or enucleation. Indications for operation were pain, enlarging tumors, uncertain diagnosis, rupture.The technique tumor...
Abstract The number of nonrenal solid‐organ transplants increased substantially in the last few decades. Many these patients develop renal failure and receive kidney transplantation. aim this study was to evaluate patient allograft survival primary, repeat, kidney‐after‐nonrenal organ transplantation using national data reported United Network for Organ Sharing ( UNOS ) from January 2000 through December 2014. Survival time each stratified into following: Group A (comparison...
Background Fibrolamellar Hepatocellular Carcinoma (FL‐HCC) is a rare primary liver tumor that usually presents in younger patients without underlying disease. Methods We queried the United Network of Organ Sharing (UNOS) database between October 1988 and January 2013 to evaluate outcomes with FL‐HCC undergoing transplantation States compared conventional (HCC). Results Sixty‐three were identified (57% female, mean age 30 years). Only one patient (2%) had an associated Hepatitis C Virus. Mean...
Experimental and preclinical evidence suggest that adoptive transfer of regulatory T (Treg) cells could be an appropriate therapeutic strategy to induce tolerance improve graft survival in transplanted patients. The University Kentucky Transplant Service Line is developing a novel phase I/II clinical trial with ex vivo expanded autologous Treg as cellular therapy renal transplant recipients who are using everolimus (EVR)-based immunosuppressive regimen.The aim this study was determine the...
Abstract Background & Aims The purpose of this study was to evaluate predictors outcomes in combined liver–kidney transplants for polycystic liver and kidney disease. Methods We queried the United Network Organ Sharing dataset performed from 1988 2013. Results Out 107 patients who had disease, 84 were women (78.5%) with a mean age 54.9 ±7.2 years. Kaplan–Meier analysis demonstrated that undergoing transplantation disease better survival than transplant alone those other indications. This...
The role of orthotopic liver transplantation for the treatment benign solid tumors (BSLT) is not well defined.To analyze outcomes in United Network Organ Sharing data set patients with a diagnosis BSLT who underwent transplantation.A retrospective analysis was performed all (N = 87,280) States from October 1, 1988, through January 31, 2013.Demographics, clinicopathological characteristics, distribution procedures by region and state, overall survival rates.During study period, 147...