A5027030981- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Antimicrobial Peptides and Activities
- Acute Lymphoblastic Leukemia research
- Inflammation biomarkers and pathways
- RNA Interference and Gene Delivery
- T-cell and Retrovirus Studies
- Long-Term Effects of COVID-19
- ATP Synthase and ATPases Research
- Peripheral Neuropathies and Disorders
- Kruppel-like factors research
- Pediatric health and respiratory diseases
- Full-Duplex Wireless Communications
- Advanced Breast Cancer Therapies
- COVID-19 Impact on Reproduction
Sheba Medical Center
2013-2024
Weizmann Institute of Science
2007-2020
Tel Aviv University
1997-2018
Appropriate immune response following COVID-19 vaccination is important in the context of disease-modifying treatments (DMTs). In a prospective cross-sectional study, we determined SARS-COV-2 IgG up to 6 months PfizerBNT162b2 414 multiple sclerosis (MS) patients and 89 healthy subjects. Protective was demonstrated untreated MS (N = 76, 100%), treated with Cladribine 48, Dimethyl fumarate 35, Natalizumab 32, Teriflunomide 39, similarly subjects 89, 97.8%). Response decreased Fingolimod 42,...
Abstract Apoptosis is an active, intrinsic cell suicide program. We recently suggested that it may have a role in the death of nigrostriatal dopaminergic neurons Parkinson's disease (PD). now report levodopa, current major therapy for PD, potent inducer apoptosis cultured postmitotic chick sympathetic neurons. Levodopa, concentration range 0.01–0.3 m M , caused characteristic apoptotic cascade shrinkage, massive membrane blebbing, and nuclear fragmentation, as evident by flow cytometry...
We analyzed biochemically and temporally the molecular events that occur in programmed cell death of mouse cerebellar granule neurons deprived high potassium levels. An hour after switching to a low extracellular K+ concentration ([K+]o), significant part genomic DNA was already cleaved high-molecular-weight fragments. This phenomenon intensified with progression process. Addition cycloheximide 4 h [K+]o deprivation resulted no loss complete recovery damaged DNA. margination nuclear...
Demyelination and axonal degeneration, hallmarks of multiple sclerosis (MS), are associated with the central nervous system (CNS) inflammation facilitated by C-X-C motif chemokine 12 (CXCL12) chemokine. Both in MS experimental autoimmune encephalomyelitis (EAE), deleterious CNS has been upregulation CXCL12 expression CNS. We investigated dynamics progression clinical EAE following spontaneous recovery, a focus on hippocampal neurogenic dentate gyrus (DG) corpus callosum (CC) spontaneously...
Antiviral adaptive immunity involves memory B cells (MBC) and T (MTC). The dynamics of MBC MTC in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescents warrant further investigation.In this cross-sectional longitudinal study, blood-derived responses were evaluated 68 anti-spike IgG-positive mild disease 2019 (COVID-19) at visit 1, between 1 7 months (median 4.1 months) after onset. SARS-CoV-2 IgG was determined by ELISA, SARS-CoV-2-specific receptor binding domain (RBD)...
Parkinson's disease (PD) is a progressive neurological disorder caused by rather selective degeneration of the dopaminergic (DA) neurons in substantia nigra. Though subject to intensive research, etiology this nigral neuronal loss still enigmatic and treatment basically symptomatic. The current major hypothesis suggests that death PD due excessive oxidative stress generated auto- enzymatic oxidation endogenous neurotransmitter dopamine (DA), formation neuromelanin presence high...
Abstract: The neurotransmitter dopamine is capable of inducing apoptosis in postmitotic sympathetic neurons via its oxidative metabolites. To detect genes whose expression transcriptionally regulated during the early stages dopamine‐triggered apoptosis, we applied differential display method to cultured neurons. One up‐regulated was identified as cyclin B2, which exhibited two waves induction and destruction, both at mRNA protein levels, resembling sequential oscillations typical successive...
Antigen-induced peripheral tolerance is potentially one of the most efficient and specific therapeutic approaches for autoimmune diseases. Although highly effective in animal models, antigen-based strategies have not yet been translated into practicable human therapy, several clinical trials using a single antigen or peptidic-epitope multiple sclerosis (MS) yielded disappointing results. In these trials, however, apparent complexity dynamics pathogenic autoimmunity associated with MS, which...
The subventricular zone (SVZ) of the lateral ventricles and subgranular (SGZ) dentate gyrus in hippocampus are known as neurogenic niches. We show that median eminence (ME) hypothalamus comprises BrdU+ newly proliferating cells co-expressing NG2 (oligodendrocyte progenitors) RIP (pre-myelinating oligodendrocytes), suggesting their differentiation toward mature oligodendrocytes (OLs). ME can generate neurospheres (NS) vitro, which differentiate mostly to OLs compared with SVZ-NS typically...
Abstract Objective To determine whether pediatric‐onset multiple sclerosis (POMS) and adults‐onset (AOMS) patients are different in initial disease severity recovery to investigate the associations with peripheral blood mononuclear cells (PBMCs) transcriptional profiles. Methods Clinical radiological of first second relapses 6‐month were analyzed 2153 (MS) compared between POMS (onset at 8–18years old) AOMS 19–40 years patients. PBMCs transcriptomes 15 gender‐matched 6 months after relapse...
Abstract Primary progressive multiple sclerosis (PPMS) affects 10–15% of patients and presents significant variability in the rate disability progression. Identifying key biological features at higher risk for fast progression is crucial to develop optimize treatment strategies. Peripheral blood cell transcriptome has potential provide valuable information predict patients’ outcomes. In this study, we utilized a machine learning framework applied baseline transcriptional profiles brain MRI...
Myelin-associated oligodendrocytic basic protein (MOBP) is a central nervous system (CNS)-specific myelin constituent important in stabilizing the unique multi-layered structure of CNS-myelin sheath. Although autoimmunity against MOBP has been associated with multiple sclerosis pathogenesis, anti-MOBP pathogenic T cells have poorly investigated as compared to other encephalitogenic proteins. We recently determined MOBP15-36 major epitope for SJL/J mice. In this study, epitope-specificity was...
Abstract Background Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration POL1 inhibitor RAM-589.555, which characterized by high permeability and bioavailability in naïve mice, ameliorates proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) suppressing activated autoreactive lymphocytes. We assessed the accessibility RAM-589.555 to central nervous system (CNS) EAE-mice...