A5054726889- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- CAR-T cell therapy research
- Additive Manufacturing and 3D Printing Technologies
- Cancer Research and Treatments
- Orthopaedic implants and arthroplasty
- Anatomy and Medical Technology
- Digital Imaging in Medicine
- Biomedical and Engineering Education
- Dental materials and restorations
- Monoclonal and Polyclonal Antibodies Research
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Oral and gingival health research
- Advanced Drug Delivery Systems
- Clinical Nutrition and Gastroenterology
- Advanced Biosensing Techniques and Applications
- Facial Trauma and Fracture Management
Aalto University
2019-2022
Oncos Therapeutics (Finland)
2014-2015
Adenoviruses are excellent immunotherapeutic agents with a unique ability to prime and boost immune responses. Recombinant adenoviruses cause immunogenic cancer cell death subsequent release of tumor antigens for antigen presenting cells, resulting in the priming potent tumor-specific immunity. This effect may be further enhanced by immune-stimulating transgenes expressed virus. We report case 38-year-old female Stage 3 metastatic micropapillary serous carcinoma ovary. She was treated Phase...
Large critical size bone defects are complicated to treat, and in many cases, autografts become a challenge due availability. In such situations, synthetic implant that can be patient-specifically designed fabricated with control over parameters as porosity, rigidity, osteogenic cues act potential substitute. this study, we produced photocuring composite resins poly(trimethylene carbonate) containing high ratios of bioactive ceramics printed porous 3D scaffolds used grafts. To enhance the...
Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of infiltrating lymphocytes (TILs) specific gene-signatures prior to treatment are linked good prognosis, while the opposite true for extensive immunosuppression. use adenoviruses as vaccines form active immunotherapy initialise tumor-specific response that targets patient's unique antigen repertoire. We report case 68-year-old male asbestos-related...
Implants of bioresorbable materials combined with osteoconductive calcium phosphate ceramics show promising results to replace and repair damaged bone tissue. Here we present additive manufacturing patient-specific porous scaffolds poly(trimethylene carbonate) (PTMC) including high amounts β-tricalcium (β-TCP). Tensile testing composite networks showed that addition reinforces the composites significantly. Three-dimensional structures containing up 60 wt % β-TCP could be built by...
A major challenge with extensive craniomaxillofacial bone reconstruction is the limited donor-site availability to reconstruct defects predictably and accurately according anatomical shape of patient. Here, patient-specific composite bioimplants, consisting cross-linked poly(trimethylene carbonate) (PTMC) networks β-tricalcium phosphate (β-TCP), are tested in vivo twelve Göttingen minipigs a large mandibular continuity defect model. The 25 mm supported by titanium plates receive either...
Meeting abstracts Advanced tumors are often immunosuppressive. Intratumoral administration of adenovirus activates Toll-like receptor signalling leading to production pro-inflammatory cytokines and activation the innate immune system. Oncolytic causes immunogenic cancer cell death