A5070326850- Forensic Toxicology and Drug Analysis
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Isotope Analysis in Ecology
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Advanced Chemical Sensor Technologies
- Neuroscience and Neuropharmacology Research
- Alcohol Consumption and Health Effects
- Advanced MRI Techniques and Applications
- Chemical Reactions and Isotopes
- Pesticide Residue Analysis and Safety
- Alkaloids: synthesis and pharmacology
- HIV, Drug Use, Sexual Risk
- Imbalanced Data Classification Techniques
- Radioactive contamination and transfer
- GABA and Rice Research
- Machine Learning in Bioinformatics
- Forensic and Genetic Research
- Forensic Fingerprint Detection Methods
- NMR spectroscopy and applications
- Radioactive element chemistry and processing
- Health, Medicine and Society
- Neurotransmitter Receptor Influence on Behavior
Institut National de Police Scientifique
2011-2023
Laboratoire de Chimie
1999
Institut Mérieux (France)
1999
Université Claude Bernard Lyon 1
1997
Institut des Sciences Biologiques
1997
New psychoactive substances (NPS) have become a serious threat for public health due to their ability be sold in the street or on internet. NPS are either derived from commercial drugs which misused (recreational rather than medical use) whose structure is slightly modified. To regulate NPS, it essential accurately characterize them, recognize molecules that were previously identified quickly elucidate of unknown ones. Most approaches rely determination exact mass obtained by high-resolution...
Abstract The applicability of isotopic analysis 13C for forensic purposes has been discussed in the case heroin. obtained results showed first that morphine acetylation induces an fractionation, so enrichment diacetylmorphine depends on both geographical origin sample and source acetic anhydride used by drug trafficker. That measurement can then be great interest determination common-batch samples (tactical intelligence purpose). Second, deacetylation also studied it appeared this allows to...
For the last ten years, quantitative isotope ratio monitoring 13C NMR (irm-13C NMR) has been successfully tested and proven as an efficient tool for determination of position-specific 13C/12C ratios. Several applications in different domains have shown interest this technique. In context origin assignment, possibility to track distribution network illicit drugs or cutting agents is prime importance. However irm-13C still suffers from a relative lack sensitivity limiting its dissemination...
Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for long time due its nephritic and carcinogenic adverse effects. It frequently appears cocaine seizures as cutting agent. Following both sanitary intelligence motivations, this molecule was chosen study, stable isotopes seemed be the most appropriate tool. A total of 228 seized samples were collected over 6‐year period, 8 standards known origin purchased. They submitted gas chromatography (GC) or...
Efficient and robust analytical methods are needed to improve the identification subsequent regulation of new psychoactive substances (NPS). NMR spectroscopy is a unique method able determine structure small molecules such as NPS even in mixtures. However, high-field analysis associated with expensive purchase maintenance costs. For more than decade, compact spectrometers have changed this paradigm. It was recently shown that dedicated workflow combining databases could identify molecular...
Despite the high complexity of seized heroin samples, isotope ratio mass spectrometric determinations 13 C/ C and 16 N/ N ratios provide relevant informations for determination their origin. This paper shows how isotopic cartion nitrogen from itself impunities contained in samples as well measurement effecrs occuring during acetylation morphine desacetylation are used markers geographical origin these drugs abuse.
Abstract The position‐specific 15 N isotope content in organic molecules, at natural abundance, is for the first time determined by using a quantitative methodology based on Nuclear Magnetic Resonance (NMR) spectrometry. NMR spectra are obtained an adiabatic “Full‐Spectrum” INEPT sequence order to make possible experiments with high signal‐to‐noise ratio (>500), reach precision standard deviation below 1‰ (0.1%). This level of required observing small changes associated effects. As...
Abstract In the battle against illicit drugs market, methodologies have been developed by forensic laboratories to address determination of origin and dismantlement trafficking route for various target molecules such as heroin cocaine. These drug profiling methods are not straightforward, especially when synthetic very pure, resulting in poorly informative impurity profiles, e.g. new psychoactive substances cutting agents. A tool based on intramolecular isotopic profiles has provide...