A5110312051- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogenic Bacteria Studies
- Genetic factors in colorectal cancer
- Streptococcal Infections and Treatments
- Cancer Genomics and Diagnostics
- Biochemical and Molecular Research
- Pancreatic and Hepatic Oncology Research
MRC Cancer Unit
2024
The University of Texas MD Anderson Cancer Center
2015-2016
β-Hemolytic group C and G streptococci (GCS-GGS; Streptococcus dysgalactiae subsp. equisimilis) emerged as human pathogens in the late 1970s. We report here draft genome sequences of four genetically distinct strains GCS-GGS isolated between 1960s 1980s. Comparative analysis these genomes may provide a deeper understanding virulence evolution.
SUMMARY Mutations in KRAS, particularly at codon 12, are frequent adenocarcinomas of the colon, lungs and pancreas, driving carcinogenesis by altering cell signalling reprogramming metabolism. However, specific mechanisms which different KRAS G12 alleles initiate distinctive patterns metabolic is unclear. Using isogenic panels colorectal lines harbouring G12A, G12C, G12D G12V heterozygous mutations employing transcriptomics, metabolomics, extensive biochemical validation, we demonstrate...