- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Ovarian function and disorders
- Parvovirus B19 Infection Studies
- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Reproductive Biology and Fertility
- Blood groups and transfusion
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Ovarian cancer diagnosis and treatment
- Cardiovascular Issues in Pregnancy
- Urological Disorders and Treatments
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Esophageal and GI Pathology
- Platelet Disorders and Treatments
- Herpesvirus Infections and Treatments
Tel Aviv University
2014-2024
Sheba Medical Center
2013-2023
John Wiley & Sons (United Kingdom)
2016
Israel Ministry of Health
2011
Bar-Ilan University
2011
National Clinical Research
2002
Temple University
2002
Weatherford College
1996-1997
Hadassah Medical Center
1997
University College London
1993
Abstract Objective To assess the value of antenatally determined observed to expected fetal lung area head circumference ratio (LHR) in prediction postnatal survival isolated, congenital diaphragmatic hernia (CDH). Methods Two groups fetuses were examined. The first group included 650 normal at 12–32 weeks' gestation, and data collected used establish a range LHR with gestational age. second retrospective multicenter study 354 isolated CDH which was measured on one occasion 18–38 gestation....
Most congenital heart defects (CHDs) are diagnosed on targeted prenatal transvaginal (TVS) or transabdominal (TAS) ultrasonography during the early second trimester at midgestation. Nevertheless, delayed diagnosis in some cardiac malformations still remains despite detailed echocardiographic examination. The present study was conducted to evaluate evolution of fetal anomalies and assess their development utero.We retrospectively reviewed 22,050 pregnant women who were divided into two...
To determine the outcome of pregnancies with documented fetal cytomegalovirus (CMV) infection and without abnormal findings on ultrasound examination magnetic resonance imaging (MRI).In this prospective cohort study pregnant women CMV infection, vertical transmission occurred during first second trimesters following primary maternal infection. Patients underwent serial prenatal scans MRI. All neonates ocular fundus examination, brain scan hearing evaluation, were then followed periodically...
Abstract Objective This study aimed to assess the detection rate of clinically significant results prenatal exome sequencing (pES) in low‐risk pregnancies and apparently normal fetuses non‐consanguineous couples. Methods A retrospective analysis pES conducted at a single center from January 2020 September 2023 was performed. Genetic counseling provided, detailed medical histories were obtained. High‐risk excluded due major ultrasound anomalies, sonographic soft markers, abnormal maternal...
Abstract Objective To describe a novel, sonographic approach for in‐utero evaluation of normal and abnormal aortic arch. Methods Aortic arch was evaluated by imaging the axial view upper fetal mediastinum. The left defined V‐shaped appearance junction between ductus arteriosus arch, with trachea situated posteriorly. Right double arches were diagnosed when great vessels appeared U‐shaped, intermediate location trachea. Results Between 1997 1999, 18 347 women scanned in three prenatal...
To describe the feasibility of diagnosing fetal congenital heart defects by transvaginal ultrasonography during first trimester pregnancy.Pregnant women presenting to Ultrasonographic Unit at Chaim Sheba Medical Center who had a diagnosis were reviewed retrospectively. Attention was paid prenatal ultrasound studies, karyotype, and pathologic examinations.Using high-resolution ultrasonography, we able detect tachycardia (one case), ectopia cordis with ventricular septal defect...
To evaluate the outcome of pregnancies with proven and well-dated primary cytomegalovirus (CMV) infection without abnormal fetal ultrasound magnetic resonance imaging (MRI) findings.This was a prospective study 38 singleton vertical transmission CMV prenatal MRI examinations. Entry requirements included precise dating pregnancy known time maternal infection. Neonatal follow-up strict requirement, all neonates having eye fundus examination, brain scan hearing evaluation. All children were...
To establish whether endometrial blood flow and thickness can predict the success rate of in-vitro fertilization, 156 cycles were evaluated. The parameters were: colour power Doppler pulsatility index (PI), resistance (RI), systolic/diastolic ratio (S/D) thickness. Each patient was studied: on day ovum retrievalpickup, embryo transfer. Non-endometrial studied age, oestrestrogen progesterone concentrations, number oocytes, embryos. Pregnancy achieved in 31 cycles. On retrieval, patients who...
To study the outcome of 50 pregnancies with documented vertical transmission cytomegalovirus infection.We recruited pregnant women (51 fetuses) primary infection and confirmed in utero transmission. Prenatal evaluation included diagnostic amniocentesis repeated ultrasound examinations. Fetal diagnosis was made after 21 weeks' gestation by based on virus isolation culture, shell vial, polymerase chain reaction (PCR). Cytomegalovirus neonates determined urinary viral birth or histologic...
To establish a nomogram for fetal vermis measurements during gestation.A prospective cross-sectional study of normal singleton pregnancies. Measurements the width (in axial plane) and height sagittal were performed by high-resolution transabdominal ultrasonography between 18 38 weeks gestation in 256 fetuses.Adequate obtained fetuses. Vermian as function gestational age biparietal diameter expressed regression equations correlation coefficients found to be highly statistically significant (P...
The reproductive outcome of women with repeated abortions or infertility was assessed following treatment by operative hysteroscopy for an intrauterine septum adhesions. A prospective follow-up study (mean +/- SD, 21.1 10.3 months) 47 patients (36 suffering from and 11 recurrent abortions) 36 adhesions (24 complaining 12 performed. pregnancy rate in infertile hysteroscopic resection 53 48% respectively. wastage who underwent decreased postoperatively 87.5 to 44.4% 86.5 42.8% Our results...
To compare the outcomes of radiofrequency ablation (RFA) and bipolar cord coagulation (BPC) methods for selective feticide in complicated monochorionic (MC) twin gestations to determine risk factors adverse pregnancy outcome.This was a retrospective cohort study all patients with MC who underwent reduction single tertiary care center between 2000 2014. We compared two respect various demographic, obstetric perinatal outcome variables.Fifty-three terminations were performed, 36 by RFA 17 BPC....
To suggest a new ultrasonographic approach for prenatal diagnosis of esophageal atresia (EA).Since 1995, whenever EA is suspected, we perform systematic multiplanar scanning the fetal upper body in order to demonstrate an pouch. This includes three image plans neck and chest: coronal, sagittal axial views cephalic direction. The scan time 20-30 min.Twenty-five pregnant patients were referred during period under study examinations due polyhydramnios and/or absent or small stomach. In six...
To evaluate the validity of prenatal diagnosis work-up for congenital cytomegalovirus (CMV) in women with primary infection.Sixty-three pregnant disease (including two twin pregnancies), referred to three tertiary perinatal centers over 4 years, underwent evaluation cytomegalovirus. Fetal was made after 21 weeks' gestation by amniocentesis and fetal blood sampling (40 subjects), or only (23 subjects).Twenty-two (35%) pregnancies showed evidence vertical transmission: 13 them funipuncture,...
Abstract Objective To describe our management of pregnancies complicated by twin reversed arterial perfusion (TRAP) sequence. Methods This was a retrospective study involving all cases TRAP sequence referred to fetal medicine unit in 3‐year period (2000–2002). Patients were routinely managed repeat sonographic surveillance with anatomical evaluation and detailed echocardiography. Cases signs impending cardiac failure treated in‐utero YAG‐laser coagulation the umbilical vessels acardiac twin....
Abstract Objective Treatment of maternal hyperthyroidism during pregnancy is complicated by the lack readily available measures thyroid status fetus. The aim this study to describe use serial in utero ultrasound measurements fetal patients being treated for Graves' disease pregnancy. Methods Over a 24‐month period, all pregnant women with attending our special Fetal Thyroid Unit were followed. Maternal was assessed function tests. size measured serially transvaginal ultrasonography between...
The object of our investigation was to evaluate the potential transvaginal echocardiography for a complete anatomic study fetal heart, and detection congenital heart diseases in low-risk pregnant patients between 13 15 weeks' gestation. High-frequency (6.5 MHz 7.5 MHz) probes were employed echocardiographic assessment. Six hundred sixty considered at low risk disease underwent utero ultrasonographic studies, neonatal records, postnatal imaging pathologic examination. four-chamber view...
Abstract Objectives Anomalies of the fetal venous system are poorly documented and their pathogenesis is not well understood. The present study was undertaken to review spectrum central veins umbilico‐portal anomalies, propose a classification system. Methods A 7‐year restrospective survey conducted. Results Nineteen fetuses showed abnormal connection between heart. Three connections cardinal veins, two which had interruption inferior vena cava, one isolated persistent left superior cava....