A5087330829- Enterobacteriaceae and Cronobacter Research
- Reservoir Engineering and Simulation Methods
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
Institute of Molecular Biology and Biophysics
2025
ETH Zurich
2025
University of Exeter
2024
The γ-tubulin ring complex (γ-TuRC) is an essential multiprotein assembly that provides a template for microtubule nucleation. γ-TuRC recruited to microtubule-organizing centers (MTOCs) by the evolutionarily conserved attachment factor NEDD1. However, structural basis of NEDD1–γ-TuRC interaction not known. Here, we report cryo-EM structures NEDD1 bound human in absence or presence activating CDK5RAP2. We found C-terminus forms tetrameric α-helical contacts lumen cone and orients its...
Abstract Outnumbering their hosts by at least a factor of 10, viruses are the most common biological entity on Earth, major drivers evolution, and greatly impact dynamics our planet’s ecosystems. While infecting bacteria eukaryotes have been extensively studied, roaming archaeal domain remain largely unexplored. In recent years, growing number described, revealing stunningly diverse range morphologies that appear unique to archaea. Detailed structural studies paramount fully understand how...