A5048018524- Cancer-related Molecular Pathways
- Caveolin-1 and cellular processes
- Cell Adhesion Molecules Research
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Neuroendocrine Tumor Research Advances
- Inflammatory mediators and NSAID effects
- Cancer Research and Treatments
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
The present study explored the anti-tumor effects of chidamide plus oxaliplatin on colorectal cancer (CRC) and examined its underlying mechanism.First, Combination Index (CI) was evaluated via CCK-8 assay. Second, monotherapy combined treatment cell proliferation, invasion, migration, apoptosis were detected. Third, whole-transcriptome RNA sequencing (RNA-seq) performed to seek potential targeted gene by which exerted effects. Fourth, validation signal pathway it regulated performed....
To evaluate the clinical significance of endocrine-like tumor cells in human colorectal carcinomas.The immunohistochemistry method (ABC) using a rabbit polyclonal antibody against chromogranin A (CGA) was employed to determine changes from surgically resected carcinoma tissues patients (35 males and 27 females, aged 19 78 years, with mean age 50.3 years). Of 62 specimens, 44 were rectal carcinomas, 18 colonic 14 lymph nodes 48 non-involvement. Dukes classification revealed cases stage A, 29...
In order to study the significance of CD(276) and CD(133) in development progression colorectal cancer (CRC), expression was detected by immunohistochemistry CRC precancerous lesions. The results showed that intensity samples higher than adenoma group non-adenoma group. single double positive were significantly correlated with lymph node metastasis, distant metastasis survival. are associated poor...