A5101776511- Yersinia bacterium, plague, ectoparasites research
- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Paleopathology and ancient diseases
- interferon and immune responses
- Forensic Entomology and Diptera Studies
- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- RNA and protein synthesis mechanisms
- Influenza Virus Research Studies
- Wildlife Ecology and Conservation
- Gut microbiota and health
University of Zurich
2019-2024
ETH Zurich
2024
University of Basel
2024
University of Tübingen
2017-2019
Abstract Egypt, located on the isthmus of Africa, is an ideal region to study historical population dynamics due its geographic location and documented interactions with ancient civilizations in Asia Europe. Particularly, first millennium BCE Egypt endured foreign domination leading growing numbers foreigners living within borders possibly contributing genetically local population. Here we present 90 mitochondrial genomes as well genome-wide data sets from three individuals obtained Egyptian...
Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, main causative agent leprosy. Leprosy is one oldest recorded and most stigmatizing diseases in history. The disease was prevalent Europe until 16th century still endemic many countries with over 200,000 new cases reported annually. Previous worldwide studies on modern European medieval M. leprae genomes revealed that they cluster into several distinct branches which two were...
Abstract The 1918 influenza pandemic was the deadliest respiratory of 20th century and determined genomic make-up subsequent human A viruses (IAV). Here, we analyze both first IAV genomes from Europe samples prior to autumn peak. diversity is consistent with a combination local transmission long-distance dispersal events. Comparison before during peak shows variation at two sites in nucleoprotein gene associated resistance host antiviral response, pointing possible adaptation humans....
The cave bear (Ursus spelaeus) is one of the Late Pleistocene megafauna species that faced extinction at end last ice age. Although it represented by largest fossil records in Europe and has been subject to several interdisciplinary studies including palaeogenetic research, its fate remains highly controversial. Here, we used a combination hybridisation capture next generation sequencing reconstruct 59 new complete mitochondrial genomes (mtDNA) from 14 sites Western, Central Eastern Europe....
Abstract Background Recent advances in sequencing have facilitated large-scale analyses of the metagenomic composition different samples, including environmental microbiome air, water, and soil, as well living humans other animals. Analyses ancient human samples may provide insights into health disease, pathogen evolution, but field is still its very early stages considered highly challenging. Results The content Egyptian mummified individuals from time periods was investigated via genetic...
Leprosy, one of the oldest recorded diseases in human history, remains prevalent Asia, Africa, and South America, with over 200,000 cases every year.1World Health Organization, Regional Office for South-East AsiaGlobal Leprosy Strategy 2016-2020: Accelerating towards a leprosy-free world (WHO Asia).2016Google Scholar,2World consultation National Programme managers, partners affected persons on Global 2021–2030: Report virtual meeting 26-30 October 2020.2020Google Scholar Although ancient DNA...
Abstract The 1918 influenza pandemic was the deadliest respiratory of 20th century and determined genomic make-up subsequent human A viruses (IAV). Here, we analyze first IAV genomes from Europe first, milder wave pandemic. diversity is consistent with local transmission frequent long-distance dispersal events in vitro polymerase characterization suggests potential phenotypic variability. Comparison second shows variation at two sites nucleoprotein gene associated resistance to host...