A5015667242- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Ethics in Clinical Research
- Actinomycetales infections and treatment
- Diphtheria, Corynebacterium, and Tetanus
- Neuroblastoma Research and Treatments
- Streptococcal Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Hematological disorders and diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Childhood Cancer Survivors' Quality of Life
- Infectious Diseases and Mycology
Emory University
2021-2025
Children's Healthcare of Atlanta
2022-2025
St. Jude Children's Research Hospital
2018-2024
Le Bonheur Children's Hospital
2021
University of Tennessee Health Science Center
2021
Bloodstream infection (BSI) is a common, life-threatening complication of treatment for cancer. Predicting BSI before onset clinical symptoms would enable preemptive therapy, but there no reliable screening test.
There are limited data describing the immune responses to COVID-19 vaccination in pediatric kidney transplant recipients, and expanding upon this information could help inform strategies unique population. We performed a prospective, observational, single-center cohort study using remnant blood samples of recipients from routine clinic visits examine longitudinal serological after vaccination. enrolled 61 who had at least 1 sample available for analysis. Sera or plasma were analyzed...
We describe the successful use of novel antifungal drug fosmanogepix to treat a chronic case multidrug-resistant cutaneous Fusarium suttonianum infection in pediatric patient with STAT3 hyper-IgE syndrome and end-stage kidney disease on peritoneal dialysis.
Importance Children undergoing treatment for leukemia are at increased risk of severe sepsis, a dysregulated immune response to infection leading acute organ dysfunction. As cancer survivors, they face high burden long-term adverse effects. The association between sepsis during anticancer therapy and dysfunction in adult survivors childhood has not been examined. Objective To determine whether is associated with subsequent chronic health conditions survivors. Design, Setting, Participants...
Abstract Background After commercial metagenomic next-generation sequencing of plasma microbial cell-free DNA (NGS-mcfDNA) became available at Children’s Healthcare Atlanta (CHOA) in 2018 with an institutional requirement for Infectious Disease (ID) consultation and approval, we observed initial period test utilization without consistent ID involvement. Subsequently assembled a Diagnostic Stewardship Team (DST) composed clinical microbiologist 3 clinicians expertise diagnosis management...
Abstract Background Patients undergoing treatment for relapsed or refractory malignancies are at high risk of life-threatening bloodstream infection (BSI). A predictive screening test BSI might allow pre-emptive therapy, but no validated is currently available. We tested the hypothesis that plasma metagenomic next generation pathogen sequencing (NGS) would predict before onset attributable symptoms. Methods enrolled 31 pediatric patients receiving malignancy in an IRB-approved prospective...
Abstract Background New culture-independent diagnostics are being investigated for diagnosis and prediction of infection. One method is microbial cell-free DNA sequencing (mcfDNA-seq), which can detect a wide range pathogens directly from plasma. Immunocompromised children who develop febrile neutropenia (FN) without documented bloodstream infection (BSI) may have an undiagnosed bacterial infection, but identification this subset difficult. The percentage episodes FN caused by that did not...
Abstract Background Diagnosis of invasive fungal infections (IFIs), a life-threatening complication cancer therapy or hematopoietic cell transplantation (HCT) can be challenging, and IFI has poor outcomes. Prediction early non-invasive diagnosis in high-risk hosts before onset symptoms could reduce morbidity mortality. Because plasma mcfDNA NGS detect infections, may predict bloodstream immunocompromised patients, we hypothesized that might also infection clinical presentation. Methods In...
Abstract Background Trichosporon species are uncommon but emerging pathogens that cause life-threatening infections resistant to amphotericin B and echinocandins. Diagnosis of deeply invasive trichosporonosis is often elusive conventional culture methods until locally advanced or disseminated disease has advanced. CT scans Pulmonary Trichosporonosis Lung Bx detected by Karius Cell-Free DNA Metagenomic Assay Plasma Methods Review cases next-generation sequencing microbial cell-free from...
Abstract Background Culture-independent diagnostics may help diagnose or predict infection; microbial cell free DNA sequencing (mcfDNA-seq), can detect a wide range of pathogens directly from plasma. Immunocompromised children who develop febrile neutropenia (FN) without documented bloodstream infection (BSI) have undiagnosed bacterial infection, but identification this is difficult, and the proportion such episodes unknown, as relative contribution non-bacterial etiologies. We analyzed...
Abstract Background In patients with bloodstream infection (BSI), true eradication of takes longer than blood culture clearance. Therefore, optimal treatment duration, especially in immunocompromised hosts, is unknown. A sensitive test microbiological response to could improve care by indicating a time for safe antibiotic discontinuation. Microbial cell-free DNA sequencing (mcfDNA-seq) predictor BSI, and we hypothesize that it might also be useful measure treatment. Methods Eligible...
Abstract Background Pediatric kidney transplant recipients (PKTR) are at risk of poor outcomes from COVID-19. Data on serologic responses to COVID-19 vaccines in PKTR remain sparse. We characterized the magnitude, breadth, and longevity SARS-CoV-2 spike protein binding antibody PKTR. Methods This single institution, prospective observational study enrolled presenting a clinic for routine care who had received or were eligible receive vaccine. Demographic data, history prior COVID-19,...
Abstract Background Management of gram-negative bacteremia (GNB) in children with cancer (CWC) is complicated by increasing rates antimicrobial resistance. Guidelines for the management CWC suspected serious bacterial infections at St. Jude Children’s Research Hospital (SJ) recommend cefepime (CEF) monotherapy empirical therapy most patients. Children evidence sepsis, recent treatment CEF or known colonization a CEF-resistant (CEF-R) organism are initially treated meropenem and/or amikacin....