A5055980271- Nitric Oxide and Endothelin Effects
- Phytochemistry and Biological Activities
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Diseases and Immunity
- Blood Pressure and Hypertension Studies
- Natural Antidiabetic Agents Studies
- Neurological Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Essential Oils and Antimicrobial Activity
- Angiogenesis and VEGF in Cancer
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Eicosanoids and Hypertension Pharmacology
Universidad Autónoma Metropolitana
2023
Mexican Social Security Institute
2023
Secretaria de Salud
2022
Universidad Autónoma del Estado de Morelos
2018-2021
Abstract Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed characterize murine model induced by daily intraperitoneal administration angiotensin II (AGII) 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage various target organs were evaluated treated animals. The results indicated...
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with no curative treatment, and available therapies aim to modify course disease. It has been demonstrated that extracts Tagetes lucida have immunomodulatory neuroprotective effects. This work induced motor damage neuroinflammation in male BALB/c mice by oral administration cuprizone (CPZ) (40 mg/kg) for five weeks. In addition, coumarins (25 were used control these variables; during experiment, animals...
Liver damage is characterized by lipid accumulation in the liver, a prooxidant/proinflammatory state, necrosis, and fibrosis. Given multifactorial conditions complexity of disease contribution oxidative stress inflammation its development, phytomedicine good option for control. was induced male C57BL/6J mice chronic administration angiotensin II (ANGII) (0.01 μg/kg/day, administered daily intraperitoneally). A hydroalcoholic extract Sechium edule root (rSe-HA), standardized cinnamic acid...
Background: Endothelial dysfunction (ED) is a marker of vascular damage and the precursor cardiovascular diseases such as hypertension, which involve inflammation organ damage. Nitric oxide (NO) produced by eNOS, induced pAKT, plays crucial role in function healthy endothelium. Methods: A combination subfractions SF1 SF3 (C4) aqueous fraction from Cucumis sativus (Cs-Aq) was evaluated to control endothelial vivo, on HMEC-1 cells assess involvement pAkt vitro. C57BL/6J mice were daily...
Background: Endothelial dysfunction (ED) is a marker of vascular damage and precursor cardiovascular diseases such as hypertension, which involve inflammation organ damage. Nitric oxide (NO), produced by eNOS, induced pAKT, plays crucial role in the function healthy endothelium. Methods: A combination subfractions SF1 SF3 (C4) aqueous fraction from Cucumis sativus (Cs-Aq) was evaluated to control endothelial vivo on HMEC-1 cells assess involvement pAkt vitro. C57BL/6J mice were injected...
Endothelial dysfunction induced by Angiotensin II (AG II) plays an important role in the pathogenesis of hypertension and is accompanied a prooxidative condition, which turn induces inflammatory state, vascular remodeling, tissue damage including kidney (Schmitt Dirsch, 2009) [1]. New drugs that can control several these pathologies are required. Sechium edule has been reported to possess antioxidant, anti-inflammatory antihypertensive activity (Ibarra-Alvarado et al., 2010) [2]. This paper...
Abstract Endothelial dysfunction (ED) is a key factor for the development of cardiovascular diseases. Due to its chronic, life-threatening nature, ED only can be studied experimentally in animal models. Therefore, this work was aimed characterize murine model induced by daily intraperitoneal administration angiotensin II (AGII) 10 weeks. Oxidative stress, inflammation, vascular remodeling, hypertension, and damage various target organs were evaluated treated animals. The results indicated...