A5092152099- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Erythropoietin and Anemia Treatment
- Cancer, Hypoxia, and Metabolism
Mansoura University
2023
Renal hypoxia is one of the currently highlighted pathophysiologic mechanisms diabetic nephropathy (DN). Both hypoxia-inducible factor-1α (HIF-1α) and HIF-2α are major regulators renal adaptive responses to hypoxia.This study aims compare effects vildagliptin (a dipeptidyl peptidase-IV inhibitor, DPP-4i) empagliflozin sodium-glucose cotransporter 2 SGLT2i) on differential expression HIF-1α/2α. Tissue prolylhydroxylase 3 (PHD3), a key regulator stability, was also in rat model. Type 1...
Abstract Background and Aims With the diabetes pandemic, chronic kidney disease is a burden, with diabetic nephropathy (DN) being primary leading cause of end-stage renal disease. Antidiabetic drugs have shown renoprotective effects via different mechanisms, among those are SGLT2 inhibitors DPP-4 inhibitors. Hypoxia-inducible factor (HIF) pathway, significant contributor to inflammation development in kidneys, major pathway that regulates erythropoietin synthesis. Prolyl hydroxylase domain...