A5077319467- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Neuroblastoma Research and Treatments
- Lipid Membrane Structure and Behavior
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
Zhejiang University of Science and Technology
2023-2025
Zhejiang University
2025
Peking University
2017
Peking University Cancer Hospital
2017
The emergence of mRNA vaccines has heralded an epoch in disease prevention and treatment. Safe efficient delivery systems are highly desired for the widespread application therapeutics. Herein, we have designed a facile synthetic pathway producing ionizable lipids featuring various branched linkers. These been integrated into lipid nanoparticles (LNPs) to improve vaccines. influence linker structure on LNPs is currently underreported, yet it undeniably exerts substantial impact outcomes....
mRNA vaccines have been revolutionizing disease prevention and treatment. However, their further application is hindered by inflammatory side effects, primarily caused delivery systems such as lipid nanoparticles (LNPs). In response to this issue, we prepared cationic lipids (mLPs) derived from mildronate, a small-molecule drug, subsequently developed the LNP (mLNP-69) comprising low dose of mLP. Compared with (sLNP) based on SM-102, commercially available ionizable lipid, mLNP-69 ensures...
Immunotherapy has emerged as a triumph in the treatment of malignant cancers. Nevertheless, current immunotherapeutics are insufficient addressing tumors characterized by tumor cells' inadequate antigenicity and microenvironment's low immunogenicity (TME). Herein, we developed novel multifunctional nanoassembly termed FMMC through self-assembly indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor 1-methyl-tryptophan prodrug (FM), Ce6, ionic manganese (Mn2+) via noncovalent interactions. The...