A5103253318- Palliative Care and End-of-Life Issues
- Polyomavirus and related diseases
- Insect Pest Control Strategies
- Antibiotics Pharmacokinetics and Efficacy
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Circadian rhythm and melatonin
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal Infections and Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Connective tissue disorders research
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Insect and Pesticide Research
- Ocular Surface and Contact Lens
- Cancer-related gene regulation
- Poisoning and overdose treatments
- Hippo pathway signaling and YAP/TAZ
- Ophthalmology and Eye Disorders
- Cancer therapeutics and mechanisms
- Neuroendocrine regulation and behavior
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Bristol
2022-2023
Bristol Royal Infirmary
2022
Oxford Brookes University
2019
Pulmonary Associates
1980
Maricopa County Department of Public Health
1980
Cardiac fibrosis is associated with increased stiffness of the myocardial extracellular matrix (ECM) in part mediated by cardiac fibroblast proliferation However, our understanding mechanisms regulating are incomplete. Here we characterise a novel mechanism involving combined activation Yes-associated protein (YAP) targets RUNX Family Transcription Factor 2 (RUNX2) and TEA Domain (TEAD). We demonstrate that enhanced interaction stiff ECM compared to soft ECM. This transcriptional co-factor,...
The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome. Once thought to be elevated as a consequence diseases, data now supports more causative role. We have previously identified CREB3L1 transcription factor that co-ordinates synthesis hypothalamus. objective here was identify mechanisms orchestrated by co-ordinate release.We mined Creb3l1 knockdown SON RNA-seq downstream target...
The second messenger, cAMP has potent immunosuppressive and anti-inflammatory actions. These have been attributed, in part, to the ability of cAMP-induced signals interfere with function proinflammatory transcription factor Nuclear Factor-kappa B (NF-κB). However, mechanisms underlying modulation NF-κB activity by remain unclear. Here we demonstrate an important role for cAMP-mediated increase nuclear actin monomer levels inhibiting activity. Elevated or forced expression a localised...
Abstract The gamma-aminobutyric acid (GABA) receptor, RDL, plays important roles in neuronal signaling and is the target of highly effective insecticides. A mutation commonly A296S, underlies resistance to several insecticides such as cyclodienes. Even though use cyclodienes has been banned, occurrence mutations substituting A296 notably high mosquitoes from countries. Here, we report a survey investigating prevalence Rdl mutant allele Laos, country where mosquito-borne diseases malaria...
Introduction: Bupropion is a monocyclic antidepressant that inhibits dopamine and norepinephrine reuptake, with significant risk cardiotoxicity in overdose cases. Case: A 32-year-old transgender man history of Human Immunodeficiency Virus (on anti-retroviral therapy), poly-substance use disorder, depression presented an intentional bupropion overdose. On arrival the patient was noted to have seizures decreased mental status. He intubated treated anti-epileptic medication. Initial EKG sinus...
ABSTRACT Objectives This study tested the use of Palliative Prognostic Index (PPI), an established cancer prognostic tool, in a general medicine group within acute setting for non-selective adult palliative care. The PPI score ranges from 0 to 15, with scores <6 indicating prognosis over 6 weeks and >6 under 3 weeks. Methods Data 256 patients seen three months by Ashford St Peter’s NHS Foundation Trust Care team were analysed. calculated correlated patient’s date death (DoD) evaluate...
The second messenger, 3', 5'-cyclic adenosine monophosphate (cAMP) has potent anti-inflammatory actions. These have been attributed to the ability of cAMP-induced signals interfere with function proinflammatory transcription factor Nuclear Factor-kappa B (NF-κB). However, mechanisms underlying modulation NF-kB activity by cAMP remain unclear. Here we demonstrate an important role for cAMP-mediated increase in nuclear actin monomer levels inhibiting NF-κB activity. Elevated or adenovirus...
Cardiac fibrosis is associated with increased stiffness of the myocardial extracellular matrix (ECM) in part mediated by cardiac fibroblast proliferation However, our understanding mechanisms regulating are incomplete. (ECM). Here we characterise a novel mechanism involving combined activation YAP targets RUNX Family Transcription Factor 2 (RUNX2) and TEA Domain (TEAD). Using collagen-coated polyacrylamide hydrogels tuneable stiffness, demonstrate that proliferation, quantified using Edu...