About
Contact & Profiles
A5078038581
Research Areas
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
University of Chicago
2018-2022
10.1038/s41590-018-0254-4
article
EN
Nature Immunology
2018-11-07
Understanding the mechanisms promoting chromosomal translocations of rearranging receptor loci in leukemia and lymphoma remains incomplete. Here we show that leukemias induced by aberrant activation β-catenin thymocytes, which bear recurrent Tcra/Myc-Pvt1 translocations, depend on Tcf-1. The DNA double strand breaks (DSBs) Tcra site translocation are Rag-generated, whereas Myc-Pvt1 DSBs not. Aberrantly activated redirects Tcf-1 binding to novel sites alter chromatin accessibility...
10.1073/pnas.2201493119
article
EN
cc-by-nc-nd
Proceedings of the National Academy of Sciences
2022-08-03
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