A5103049648- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Cardiac Ischemia and Reperfusion
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Parvovirus B19 Infection Studies
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Business Process Modeling and Analysis
- Pharmacological Effects and Assays
- Organ Transplantation Techniques and Outcomes
- Cardiac Fibrosis and Remodeling
- Herpesvirus Infections and Treatments
- Advanced Materials and Mechanics
- HIV, Drug Use, Sexual Risk
- Cardiovascular Effects of Exercise
- Sex and Gender in Healthcare
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Pulmonary Hypertension Research and Treatments
Ralph H. Johnson VA Medical Center
2023-2025
University of Colorado Boulder
2018-2025
Background Biological sex is an important modifier of cardiovascular disease and women generally have better outcomes compared with men. However, the contribution cardiac fibroblasts (CFs) to this sexual dimorphism relatively unexplored. Methods Results Isoproterenol (ISO) was administered rats as a model for chronic β-adrenergic receptor (β-AR)-mediated disease. ISO-treated males had higher mortality than females also developed fibrosis whereas did not. Gonadectomy not abrogate difference....
Medical implants with fixed geometry have many clinical applications but are limited by the dynamic nature of human physiology. To overcome this barrier, focus has shifted to stimuli-responsive materials capable changing their on demand, such as liquid crystalline elastomers (LCEs). Here, we report development and biological performance LCE-gold nanorod (LCE-AuNR) nanocomposites engineered for use in optically reconfigurable medical devices. First, maximized strain response force output...
Background and aim: Cytomegalovirus (CMV) remains a critical post-transplant opportunistic infection despite significant advancements in monitoring therapy. The impact of African-American (AA) race on CMV risk outcomes has been insufficiently studied. This study aimed to determine secular trends the incidence D+/R− mismatching evaluate their association with AA clinical outcomes. Methods: single-center longitudinal cohort involved adult kidney recipients transplanted between...
Soliman, Karim M.; Anand, Prince Perry, Amy; Cheungpasitporn, Wisit; Daoud, Ahmed; Kamal, Ahmed I.; Fulop, Tibor; DuBay, Derek Author Information
Cardiac fibrosis and dysfunction, hallmarks of debilitating heart disease, are driven by fibroblast activation protein alpha (FAP). The specificity FAP to the disease creates an opportunity for directed drug delivery, as delineates fibrotic region. We leverage this vulnerability target region heart, using anti-FAP antibody-modified nanoparticles (NPs) that encapsulate release highly specific inhibitor, talabostat. NP crosslinking with FAP-sensitive peptide attenuates passive release, which...
Abstract Background The goal was to determine trends in immunosuppression use and its impact on cytomegalovirus (CMV) outcomes over the past 10 years. Methods This a single‐center longitudinal cohort study of adult kidney recipients transplanted between Jan 2012 June 2021. Baseline follow‐up data were gathered via chart abstraction analyzed using univariate multivariate analyses. Results Of 2392 transplants conducted, 131 patients did not meet inclusion criteria. mean age 52 years, 41%...
Introduction: Biological sex is an important modifier of cardiovascular disease (CVD). However, women and female animals have traditionally been excluded from clinical trials most preclinical research studies, resulting in therapeutics that are not as effective, or with different side effects, relative to men. Methods Results: We show here expression α- β-adrenergic receptors, cardiac stiffness, myofibroblast proliferation, fibrotic markers sexually dimorphic at baseline. To determine...