A5039306098- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Congenital Heart Disease Studies
- Meningioma and schwannoma management
- Myasthenia Gravis and Thymoma
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Thyroid and Parathyroid Surgery
- Genomics and Chromatin Dynamics
- Signaling Pathways in Disease
Heidelberg University
2025
University Hospital Heidelberg
2025
German Center for Lung Research
2025
Essen University Hospital
2019-2022
University of Duisburg-Essen
2019
Abstract The SWI/SNF chromatin remodeling complex has been found mutated in a wide range of human cancers, causing alterations gene expression patterns, proliferation and DNA damage response that have linked to poor clinical prognosis. Here, we investigated weather knockdown ARID1B, one two mutually exclusive subunits within the complex, can sensitize colorectal cancer cell lines other subunit, ARID1A, ionizing radiation (IR). ARID1A-mutated (CRC) are selectively sensitized IR after siRNA...
Among the different subtypes of invasive lung adenocarcinoma, lepidic predominant adenocarcinoma (LPA) has been recognized as lowest-risk subtype with good prognosis. The aim this study is to provide insight into heterogeneity within LPA tumors and better understand influence other sub-histologies on survival outcome. Overall, 75 consecutive patients in pathologic stage I (TNM 8th edition) who underwent resection between 2010 2022 were included retrospective, single center analysis....
Pulmonary arteriovenous malformations (PAVMs) are rare vascular of the lungs. Direct communication pulmonary arteries to veins is defining characteristic allowing venous blood bypass capillary system and avoiding an efficient oxygenation process. The complexity pathology lies not only in variety its manifestations, but also choice most appropriate effective treatment. We present a case complex PAVM associated with persistent foramen ovale, stroke as onset symptom. Despite timely...
ABSTRACT Background Robot‐assisted thoracic surgery (RATS) is increasingly becoming the preferred surgical method for resection of thymomas. We initiated current study to evaluate perioperative outcomes and early recurrence associated with approach. Methods In this retrospective cohort study, 35 patients were included in RATS group compared 29 who underwent open between 2010 2022 histologically confirmed large thymoma > 50 mm TNM Stages I, II, IIIa. Results Histologic subtypes pathologic...
ARID1A is frequently mutated in colorectal cancer (CRC) cells. Loss of function compromises DNA damage repair and increases the reliance tumor cells on ATR-dependent pathways. Here, we investigated effect ionizing radiation (IR), combination with ATR inhibitors (ATRi) CRC cell lines proficient deficient ARID1A. The concept selective vulnerability to ATRi was further tested an ex vivo system by using ATP-tumor chemosensitivity assay (ATP-TCA) from untreated patients, without expression. We...