A5080421269- Health Systems, Economic Evaluations, Quality of Life
- Global Health Care Issues
- Healthcare Policy and Management
- Cardiovascular Issues in Pregnancy
- Healthcare Systems and Challenges
- Ubiquitin and proteasome pathways
- Vaccine Coverage and Hesitancy
- Cardiac, Anesthesia and Surgical Outcomes
- Health Services Management and Policy
- Child and Adolescent Health
- Primary Care and Health Outcomes
- Environmental and Social Impact Assessments
- Heart Failure Treatment and Management
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Health disparities and outcomes
- Global Health Workforce Issues
- Protease and Inhibitor Mechanisms
- Pharmaceutical Economics and Policy
- Protein Degradation and Inhibitors
- Nursing Roles and Practices
University of Kansas Medical Center
2023-2024
Trinity College Dublin
2019
European Commission
2019
Head and neck squamous cell carcinoma (HNSCC) is a major health concern due to its high mortality from poor treatment responses locoregional tumor invasion into life sustaining structures in the head neck. A deeper comprehension of HNSCC mechanisms holds potential inform targeted therapies that may enhance patient survival. We previously reported doublecortin like kinase 1 (DCLK1) regulates cells. Here, we tested hypothesis DCLK1 proteins within invadopodia facilitate invasion. Invadopodia...
Abstract Background Vaccination is one of the most cost-effective public health interventions available and main tool for primary prevention communicable diseases. However, EU facing increasing outbreaks vaccine preventable diseases, while some fatal cases measles diphtheria have been reported. Methods The presented report based on work Expert Panel effective ways investing in Health, which was informed by a literature review factors (enablers obstacles) influencing vaccination uptake....
Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, series of small molecule inhibitors were screened for antitumor efficacy. The potent analog, acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone (DiFiD; A-DiFiD), demonstrated strong cellular JUN proto-oncogene, activator protein 1 (AP-1) transcription factor subunit (JUN, c-Jun) antagonism. c-Jun, an oncogenic factor,...
Introduction The National Centre for Pharmacoeconomics (NCPE) assesses the cost-effectiveness of new drugs which reimbursement by healthcare payer, Health Service Executive (HSE), is sought in Ireland. This research aims to create a systematic approach NCPE review group (RG) assess each models submitted applicant creating model appraisal guidelines. Methods RG consists clinical, statistical and health economic expertise. In order systematically appraise HTA submission, includes model, clear...
Introduction In 2018, the National Centre for Pharmacoeconomics (NCPE) was commissioned to conduct a health technology assessment (HTA) of one first commercially available chimeric antigen receptor (CAR) T-cell therapies, tisagenlecleucel. CAR T-cells are major advance in personalized cancer treatment, demonstrating promising outcomes relapsed/refractory pediatric acute lymphoblastic leukemia (pALL). However, results based on short-term follow up, limiting their value predicting long-term...