A5101818575- Acute Myeloid Leukemia Research
- Genomics and Phylogenetic Studies
- Retinoids in leukemia and cellular processes
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Acute Lymphoblastic Leukemia research
- Micro and Nano Robotics
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Genetics, Bioinformatics, and Biomedical Research
- Immune Cell Function and Interaction
- Chromosomal and Genetic Variations
- Gene expression and cancer classification
- Molecular Communication and Nanonetworks
- MicroRNA in disease regulation
- Chronic Myeloid Leukemia Treatments
- Autoimmune and Inflammatory Disorders Research
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Photosynthetic Processes and Mechanisms
- Blood groups and transfusion
- COVID-19 and healthcare impacts
- Scientific Computing and Data Management
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2019-2025
Shaanxi Provincial People's Hospital
2020-2025
Isuzu Motors (United States)
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Guangxi Medical University
2022-2024
First Affiliated Hospital of GuangXi Medical University
2022-2024
Zhejiang Cancer Hospital
2024
Wuhan University
2022-2023
Guangxi Center for Disease Prevention and Control
2023
Recent transcriptome studies have revealed that a large number of transcripts in mammals and other organisms do not encode proteins but function as noncoding RNAs (ncRNAs) instead. As millions are generated by large-scale cDNA EST sequencing projects every year, there is need for automatic methods to distinguish protein-coding from accurately quickly. We developed support vector machine-based classifier, named Coding Potential Calculator (CPC), assess the potential transcript based on six...
Despite the growing interest in motion mechanisms and application potential of individual active colloids/particles micro/nanorobotics, their aggregation for higher-ordered mesostructures remains a significant challenge due to complexity control dynamics. Here, magnetic trimer-like microrobot composed three Janus colloids with different diameters exhibited multimodal locomotion, frequency-dependent reconfigurability, contactless manipulation 3D environment. Various locomotion modes excited...
Abstract Motivation: The rapid accumulation of single amino acid polymorphisms (SAPs), also known as non-synonymous nucleotide (nsSNPs), brings the opportunities and needs to understand predict their disease association. Currently published attributes are limited, detailed mechanisms governing association a SAP remain unclear thus, further investigation new improvement prediction desired. Results: A dataset was compiled from Swiss-Prot variant pages. We extracted demonstrated effectiveness...
Histone methylation is an important epigenetic mechanism that plays essential role in regulating gene expression mammalian cells. To understand its influence on inflammation, of H3K4, H3K9, H3K36, H3K79, and H4K20, the most common histones methylated inflammatory response was analyzed murine RAW264.7 cells bone marrow-derived macrophages (BMDMs) upon lipopolysaccharide (LPS) stimulation. LPS stimulation resulted enhanced at H3K4 H3K9 both BMDMs. further confirm whether LPS-stimulated H3K4me2...
Abstract Background With the rapid growth of genome sequencing projects, browser is becoming indispensable, not only as a visualization system but also an interactive platform to support open data access and collaborative work. Thus customizable framework with rich functions flexible configuration needed facilitate various research projects. Results Based on next-generation web technologies, we have developed general-purpose ABrowse which provides browsing experience, work support. By...
Abstract Tolerance to bacterial components represents an essential regulatory mechanism during infection. Bacterial lipoprotein (BLP)-induced tolerance confers protection against microbial sepsis by attenuating inflammatory responses and augmenting antimicrobial activity in innate phagocytes. It has been well-documented that BLP tolerance-attenuated proinflammatory cytokine production is associated with suppressed TLR2 signalling pathway; however, the underlying mechanism(s) involved...
Plant organelle genomes are a valuable resource for evolutionary biology research, yet their genome architectures, patterns and environmental adaptations poorly understood in many lineages. Rhodiola species is type of flora mainly distributed highland habitats, with high medicinal value. Here, we assembled the three (R. wallichiana, R. crenulata sacra) collected from Qinghai-Tibet plateau (QTP), compared structure, gene content, structural rearrangements, sequence transfer evolution...
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome, and the overall survival of adult patients poor. Ruxolitinib, Janus kinase (JAK) 1/2 inhibitor, has shown promise in treating HLH exerts synergistic effects when combined with dexamethasone. Our pilot study preliminarily demonstrated that combination ruxolitinib dexamethasone (the Ru-D regimen) had high response rate led to favorable short-term outcomes patients. In this prospective phase 2 clinical trial, we...
<div class="section abstract"><div class="htmlview paragraph">Since most of the existing studies focus on identification yaw stable region, but ignore roll this article presents a software tool YRSRA for calculating both and region ground vehicle system with 5G-V2X. And frequency rollover instability commercial vehicles such as trucks buses is not low, cost accidents often greater than accidents. Therefore, it necessary to identify stability at same time. Firstly, iterative model...
Cancer/testis antigen HCA587, also known as MAGE-C2, highly expressed in a wide range of malignant tumors with unique immunological characteristics, serves potential target for tumor immunotherapy. Synthetic long peptides from HCA587 (HCA587 SLP) were proved to be immunogenic and promising the application cancer vaccine composed Freud's adjuvant (FA) CpG 1826, whereas, scarce CD8+ T cell response may limit their anti-tumor effects during previous research. In this study, notwithstanding...
Saxifraga species are widely distributed in alpine and arctic regions the Northern hemisphere. Highly morphological diversity within this genus brings great difficulties for identification, their typical highland living properties make it interesting how they adapt to extreme environment. Here, we newly generated chloroplast (cp) genomes of two compared them with another five cp understand characteristics potential roles adaptation. The genome size, structure, gene content, GC codon usage...
Recently, platelet to white blood cell ratio (PWR) was reported as an independent prognostic predictor in acute promyelocytic leukemia. Acute myeloid leukemia (AML) often presents with abnormal counts and (WBC) at disease diagnosis. However, the clinical impact of PWR on cytogenetically normal AML (CN-AML) is still unclear. Therefore, we evaluate its CN-AML patients.We recorded information time diagnosis, calculated WBC 338 patients CN-AML. To assess value PWR, divided into low, intermediate...
With the rapid progress of biological research, great demands are proposed for integrative knowledge-sharing systems to efficiently support collaboration researchers from various fields. To fulfill such requirements, we have developed a data-centric platform WebLab biologists fetch, analyze, manipulate and share data under an intuitive web interface. Dedicated space is provided users store their input analysis results. Users can upload local or fetch public remote databases, then perform...
Abstract Summary: We have developed a package named Application for Bioinformatics Computing Grid (ABCGrid). ABCGrid was designed biology laboratories to use heterogeneous computing resources and access bioinformatics applications from one master node. is very easy install maintain at the premise of robustness high performance. implement mechanism update all databases in worker nodes automatically reduce workload manual maintenance. backup task method self-adaptive job dispatch approach...
Objective: The study aims to investigate the effects of miR-221-3p in bone marrow mesenchymal stem cell (BMMSC)-derived microvesicles (MVs) on cycle, proliferation and invasion acute myelocytic leukemia (AML). Methods: Bioinformatics was used predict differentially expressed miRNAs (DEmiRNAs) AML. morphology BMMSC-derived MVs observed under an electron microscope, positional relation OCI-AML2 cells by a fluorescence microscope. MTT, Transwell, flow cytometry assays were analyze cells....