A5056456133- Adipose Tissue and Metabolism
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Heart Failure Treatment and Management
- Infant Nutrition and Health
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Pediatric Hepatobiliary Diseases and Treatments
IRCCS Humanitas Research Hospital
2023-2024
National Research Council
2023
Humanitas University
2023
Azienda Ospedaliera Universitaria Integrata Verona
1990
BACKGROUND: Metabolic distress is often associated with heart failure preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities HFpEF. How metabolic changes affect myocardial in the context of HFpEF not known. METHODS: We found that ApoE knockout mice fed Western diet recapitulate many features Single-cell RNA sequencing was used for expression analysis CD45 + cardiac cells to evaluate involvement diastolic...
In view of the possible relation between pancreatic function and cystic fibrosis (CF) gene mutations, a detailed study on Italian patients was performed. Seventy insufficient 48 sufficient were included after very accurate characterisation their digestive function, all performed in same CF centre. The deletion F508 tested to define patients9 genotypes. results confirm that mutation correlates with insufficiency, is recessive other, as yet unreported, mutant alleles determine sufficiency. An...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is often associated metabolic distress and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities HFpEF. How changes impact myocardial in the context of HFpEF not known. Methods We generated model by feeding ApoE knockout (ApoE KO) mice high-fat diet (HFD), used single-cell expression analysis (scRNA-seq) on CD45+ cardiac cells to evaluate involvement inflammation. By focusing...