A5039144308- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Acute Lymphoblastic Leukemia research
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- Connective tissue disorders research
- Blood disorders and treatments
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Ovarian function and disorders
- Immunodeficiency and Autoimmune Disorders
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Soft tissue tumors and treatment
- Platelet Disorders and Treatments
- Lymphadenopathy Diagnosis and Analysis
- DNA and Nucleic Acid Chemistry
- Viral Infections and Immunology Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Complement system in diseases
Seattle Children's Hospital
2022-2025
University of Washington
2012-2025
University of Washington Medical Center
2007-2023
ARUP Laboratories (United States)
1999-2003
University of Utah
1999-2003
Kaiser Permanente Anaheim Medical Center
2003
The University of Texas MD Anderson Cancer Center
2003
University Pathologists
2001-2003
Health Sciences Centre
2003
Sunnybrook Health Science Centre
2003
Follicular lymphoma (FL) is the most common form of low-grade non-Hodgkin's lymphoma. Transformation to diffuse large B cell (DLBCL) an important cause mortality. Using cDNA microarray analysis we identified 113 transformation-associated genes whose expression differed consistently between serial clonally related samples FL and DLBCL occurring within same individual. Quantitative RT-PCR validated results assigned blinded independent group 20 FLs, DLBCLs, five transformed lymphoma-derived...
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated susceptibility locus for PCOS mapping to the fibrillin-3 gene, presence fibrillin proteins normal and polycystic ovaries has not been characterized. This study compared contrasted fibrillin-1, -2, -3 localization ovaries. Immunohistochemical stainings from 21 controls 9 patients with were performed. Fibrillin-1 was ubiquitous ovarian connective tissue....
Septins, a highly conserved family of GTP-binding, filament-forming proteins, serve as scaffolds and diffusion barriers in various cellular processes. SEPTIN6 is involved hematopoiesis, assisting cell division cytokinesis. We present the second reported case SEPTIN6-related disease with X-linked congenital neutropenia, tetraploid precursors, multinucleated myeloid cells associated unique finding B deficiency abnormal initial NBS. A full-term male infant uncomplicated delivery screened...
BCL-2 is an antiapoptotic protein overexpressed in follicular lymphomas, principally as a result of the t(14;18)(q32;q21), and useful distinguishing lymphoma (usually positive) from hyperplasia (BCL-2 negative). also other types without t(14;18), including marginal zone B-cell lymphoma, because other, poorly understood mechanisms. It has been suggested that immunoreactivity can distinguish between malignant reactive negative) B cells. In this study, we evaluated 26 spleen, 10 abdominal lymph...
We compared 2 commercial plasma procoagulant phospholipid activity (PPA) assays, chromogenic, using bound annexin V to capture phosphatidylserine-containing microparticles, and clot-based. In both, anionic phospholipids accelerated activation of prothrombin by factor Xa. PPA levels were lower in the chromogenic vs clot-based assay, with poor correlation between methods: normal samples, mean ± SD, 27 17 590 414 nmol/L (n = 24; r(2) 0.29) patient 45 44 401 330 51; 0.26). Recovery...
The expression profiles of eight cell lines derived from T‐cell malignancies were compared to CD4‐positive T‐cells using cDNA microarray technology. Unsupervised hierarchical clustering 4364 genes demonstrated substantial heterogeneity resulting in four distinct groups. While no found be uniformly up‐ or down‐regulated across all lines, we observed 111 over‐expressed (greater than two‐fold) and 1118 the lymphomas as a group when T‐cells. These included involved cytokine signaling, adhesion,...
CD200 is a membrane bound glycoprotein that expressed by variety of normal tissues and hematopoietic malignancies. Flow cytometric analysis expression has utility in the evaluation mature B-cell neoplasms, myeloma, acute leukemia; however, nonhematopoietic malignancies not been extensively studied.We studied 14 cases biopsy proven pulmonary small cell carcinoma which discrete CD45 negative, CD56 positive abnormal population was identified flow cytometry. We retrospectively evaluated these...
Background Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limited that presents with cervical lymphadenopathy systemic symptoms. Histologic evaluation often necessary to differentiate KFD from other entities. Methods Electronic medical records diagnostic material were reviewed for 14 children diagnosed 6 infectious mononucleosis (IM) 2013-2021. Four cases of further characterized using targeted DNA-based next-generation sequencing. Results Systemic symptoms present in 86% (n =...
Lineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage another (ie, lymphoid myeloid) with retention baseline genetics. This phenomenon was originally observed in infants B-lymphoblastic (B-ALL)
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is an indolent non-Hodgkin rarely seen in pediatric patients. MALT most commonly involves the gastrointestinal tract or peri-orbital tissues, potentially as sequela chronic antigenic stimulation immune dysregulation. Rare cases arising from gynecologic have been reported older adult We present unique case a 16-year-old postpubescent female with localized to tract, who initially presented abdominal...