A5008128493- Diabetes Treatment and Management
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- Biochemical Analysis and Sensing Techniques
Joslin Diabetes Center
2022-2025
Harvard University
2025
University of Gothenburg
2018
Bariatric surgery is a potent therapeutic approach for obesity and type 2 diabetes but can be complicated by post-bariatric hypoglycemia (PBH). PBH typically occurs 1 to 3 hours after meals, in association with exaggerated postprandial levels of incretins insulin.
To determine whether continuous glucose monitoring (CGM) can reduce hypoglycaemia in patients with post-bariatric (PBH).
The “hunger” hormone, ghrelin, is powerfully orexigenic. Even in the absence of hunger, ghrelin delivery to rats increases consumption chow, as well palatable foods, and motivated behaviour for food rewards. Inspired by finding that selection chow offered a choice diet (lard, sucrose or chow) even bingeing on high‐fat diet, we aimed explore whether effects motivation extend regular chow. Rats were conditioned lever press either pellets progressive ratio ( PR ) operant conditioning task....
ABSTRACT Context Post‐bariatric hypoglycemia (PBH) is a complication of bariatric surgery including Roux‐en‐Y gastric bypass (RYGB). It remains unclear why only some individuals develop PBH. Objective To identify clinical characteristics distinguishing post‐RYGB with PBH, versus without symptomatic (RYGB non‐hypo). Design and Setting Cross‐sectional observational study in academic referral centre. Adults 18–70, current diabetes, were recruited into three groups: (1) PBH ( n = 39); (2) RYGB...
Post-bariatric hypoglycemia (PBH) is an increasingly recognized complication of bariatric surgery, with prevalence up to 36% after gastric bypass. Hypoglycemia typically follows postprandial glycemic spikes. Continuous glucose monitors (CGM) can alert patients high or low sensor (SG), allowing treatment and prevention severe hypoglycemia. The aim this study (NCT03353415) was determine whether CGM, currently indicated only for diabetes, could reduce in PBH. In open label, nonrandomized,...
Abstract Disclosure: A. Grover: None. A.L. Sheehan: C. Cummings: M. Farahmandsadr: H. Saeed: A.M. Puleio: D.C. Simonson: Stock Owner; Self; Phase V Technologies, GI Windows. Patti: Consulting Fee; AstraZeneca, MBX-Biosciences, Hanmi Pharmaceutical. Other; DSMB: Fractyl Health, Inc. Introduction: Post-bariatric hypoglycemia (PBH) is a severe, disabling complication of Roux-en-Y gastric bypass (RYGB). We aimed to identify clinical characteristics distinguishing patients with severe PBH vs....