A5021044213- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Parvovirus B19 Infection Studies
- Health and Medical Studies
- Reproductive System and Pregnancy
- Renal and related cancers
- Medical Imaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Pregnancy and Medication Impact
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Genomic variations and chromosomal abnormalities
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell death mechanisms and regulation
- Genetic factors in colorectal cancer
- Organ and Tissue Transplantation Research
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Ovarian function and disorders
Fulda University of Applied Sciences
2018-2025
Agroécologie
2025
Wake Forest University
2023-2024
University Hospital of Basel
2000-2019
Institut für Frauengesundheit
2016
Essen University Hospital
2005-2015
Olgahospital
2015
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2009-2015
University of Basel
2000-2014
Bern University of Applied Sciences
2013
The National Institute of Child Health and Human Development Fetal Cell Isolation Study (NIFTY) is a prospective, multicenter clinical project to develop non-invasive methods prenatal diagnosis. initial objective was assess the utility fetal cells in peripheral blood pregnant women diagnose or screen for chromosome abnormalities.Results fluorescence situ hybridization (FISH) analysis on interphase nuclei recovered from maternal were compared metaphase karyotypes obtained by amniocentesis...
Elevated temperatures impair pollen performance and reproductive success, resulting in lower crop yields. The tomato (Solanum lycopersicum) anthocyanin reduced (are) mutant harbors a mutation FLAVANONE 3-HYDROXYLASE (F3H), impaired flavonol antioxidant biosynthesis. are has seed set relative to the VF36 parental line, phenotypes that accentuated at elevated temperatures. Transformation of with wild-type F3H gene, or chemical complementation flavonols, prevented temperature-dependent reactive...
Basal cell carcinoma (BCC) is the most common skin cancer in humans, and although metastasis rarely occurs, tumor cells are nevertheless able to invade destroy surrounding tissue. Intralesional injection of IFN-alpha has been found be highly effective inducing BCC regression by an unknown mechanism. We show that untreated patients, express CD95 ligand, but not receptor, which may allow expansion averting attack activated receptor-positive lymphoid effector cells. The ligand functional as...
In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation via calcium-dependent mRNA stabilization. We performed a mutational analysis the 8 AUUUA motifs located in 3'-untranslated region IL-3 mRNA, and analyzed effect on stability PB-3c cells. Similar to endogenous exogenous transcripts had short half-life were stabilized stimulation calcium influx by ionomycin. Specific mutation 3 almost same stabilizing as deletion entire AU-rich region. Mutating even...
Abstract Introduction The efficacious analysis of fetal loci involving point mutations from circulatory DNA in maternal plasma is hindered by the preponderance DNA. It has recently been shown that size difference between and species can be used for selective enrichment plasma. We have now tested this approach detection a mutation fibroblast growth factor receptor 3 (FGFR3) gene causes achondroplasia. Methods Circulatory was extracted size‐fractionated agarose gel electrophoresis. fraction...
Pregnancies with a Rhesus constellation still present considerable obstetric problem. In addition, pregnancies male D fetuses are more severely affected by haemolytic disease of the newborn, requiring transfusions in utero and having three fold higher mortality than female fetuses. Furthermore, almost 150 X-linked genetic deficiencies have now been characterised, increasing need for prenatal sex determination at risk such disorder. order examine these two important fetal loci free manner, we...
We analyzed circulating cell-free DNA in the serum of patients with benign and malignant breast disease healthy individuals to determine its diagnostic value.Serum samples were obtained from 50 individuals, 33 32 disease. Circulatory was extracted samples. Cell-free quantified by real-time quantitative PCR for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. Tissue lesions histopathologically examined.The mean levels 41,149 genome equivalents (GE)/mL disease, 30,826 GE/mL 13,267...
Prenatal care has been significantly influenced by the introduction of non-invasive prenatal testing (NIPT) for aneuploidies in 2012. The aim this study was to describe current impact NIPT on care.We performed a retrospective data analysis including all women with singleton pregnancies who presented first trimester screening (FTS) between 1 October 2011 and 30 March 2013 those seeking NIPT. According results FTS were categorised into three risk groups: low aneuploidy (<1:300), intermediate...
Cord blood from deliveries at term can be used for HPC transplantation. The objective of this study was to determine the amounts cord nucleated cells (NCs) and HPCs that were collectable preterm deliveries.Cord collected between 22 36 weeks gestation compared with regard volume, NC count (/mL), CD34+ cell counts per sample different gestational ages.A correlation found age (r = 0.52, p<0.001), an inverse relation - 0.68, p<0.001). independent 0.13, p NS), no significant difference early...
In order to assess the potential biomolecules for breast cancer, we analyzed in parallel levels of cell-free glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and nucleosomes serum samples from patients with benign malignant tumors. The DNA obtained by quantitative PCR were compared those enzyme-linked immunosorbent assay (ELISA).Twenty-three tumors, 27 32 age-matched healthy women recruited. amounts ELISA GAPDH measured real-time PCR. correlation between nucleosome was examined using...