A5109738269- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Calcium signaling and nucleotide metabolism
- Liver physiology and pathology
- Electron Spin Resonance Studies
- Algal biology and biofuel production
- Anorectal Disease Treatments and Outcomes
- Genomics and Phylogenetic Studies
- Enzyme function and inhibition
- Electrochemical sensors and biosensors
- Polyamine Metabolism and Applications
- Health, Medicine and Society
- Oil Spill Detection and Mitigation
- Cardiac Ischemia and Reperfusion
- Research studies in Vietnam
- Nanoparticles: synthesis and applications
- Neurological Disease Mechanisms and Treatments
- Childhood Cancer Survivors' Quality of Life
- Growth Hormone and Insulin-like Growth Factors
- Health Systems, Economic Evaluations, Quality of Life
- Amino Acid Enzymes and Metabolism
de Duve Institute
2003-2017
UCLouvain
1969-2015
Institut National du Cancer
2011
KU Leuven
2003
University of Amsterdam
1990-1992
Amsterdam UMC Location University of Amsterdam
1990
Physiol (Belgium)
1969
In hepatocytes from fasted rats, several amino acids are known to stimulate glycogen synthesis via activation of synthase. The hypothesis that an increase in cell volume resulting acid uptake may be involved the stimulation is supported by following observations. 1) extent both metabolizable and nonmetabolizable was directly proportional their ability volume, except for proline, which stimulated more than could accounted volume. 2) Both swelling were prevented when incubated hyperosmotic...
1. A parallel dose-dependent activation of histone kinase, phosphorylase kinase and was observed in isolated hepatocytes incubated the presence glucagon; effect suboptimal concentrations glucagon antagonized by insulin. 2. An which not accompanied a stable change activity with phenylephrine, isoproterenol or vasopressin as well on decapitation unanesthetized animals. dissociation two enzymic activities also high concentration glucose, strongly inactivated no kinase. 3. The phenylephrine...
We have recently shown that conditions known to activate AMP-activated protein kinase (AMPK) in primary beta-cells can trigger their apoptosis. The present study demonstrates this is also the case MIN6 beta-cell line, which was used investigate underlying mechanism. Sustained activation of AMPK induced by culture with adenosine analogue AICA-riboside or at low glucose concentrations. Both a sequential AMPK, c-Jun-N-terminal (JNK) and caspase-3. effects on JNK apoptosis were demonstrated...
Studies of Langendorff-perfused rat hearts have revealed a biphasic response the mitochondrial respiratory chain to global ischaemia. The initial effect is 30-40% increase in rate glutamate/malate oxidation after 10 min ischaemia, owing an capacity for NADH oxidation. This followed by progressive decrease these oxidative activities as ischaemia prolonged, apparently damage Complex I at site subsequent dehydrogenase component. exacerbated reperfusion, which causes further activity and also...
The mechanism linking the stimulation of liver glycogen synthesis to swelling induced either by amino acids or hypotonicity was studied in hepatocytes, gel-filtered extracts, and purified preparations particulate which glycogen-metabolizing enzymes are bound. High concentrations KCl, but not potassium glutamate, were found inhibit permeabilized hepatocytes. Similarly, physiological (30-50 mM) Cl- ions also synthase phosphatase vitro, whereas 10-20 mM ions, a concentration swollen did...
Salinity and drought are significant abiotic stresses affecting plant growth productivity. To convert arid saline coral sandy soil in the Vietnamese archipelago into arable land, this study isolated evaluated salinity tolerance exopolysaccharide (EPS) production of Bacillus velezensis TSD5 strain from Vietnam. EPSTSD5 was estimated to have a molecular weight 1.09 × 105Da based on its intrinsic viscosity, with monosaccharide components consisting glucose, rhamnose, mannose (of which is...
Swelling of hepatocytes increases the concentration inositol 1,4,5‐trisphosphate, Ca 2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, activation phosphorylase by suboptimal concentrations vasopressin or angiotensin II was partly antagonized.
Mục tiêu: Đánh giá hiệu quả điều trị bằng tiêm botulinum toxin A (Dysport ở bệnh nhân loạn trương lực cổ nguyên phát tại viện đa khoa Tâm Anh Hà Nội. Phương pháp: Nghiên cứu mô tả và quan sát, không can thiệp trên tất cả được Bệnh từ tháng 11 năm 2022 đến 4 2024. Kết quả: Có 17 (12 nam 5 nữ) thoả mãn tiêu chuẩn đưa vào nghiên cứu. Điểm Tsui trước là 9.71 4.34. Các cơ lựa chọn nhiều nhất ức đòn chũm, gối đầu, bán gai đầu với tổng liều 311.76 88.89 đơn vị. Thời gian bắt đáp ứng 10.53 5.81...
Các đảo nổi ở quần san hô thuộc tỉnh Khánh Hòa có điều kiện khí hậu vô cùng khắc nghiệt, chất đất chủ yếu là cát khô cằn, khó giữ nước, nghèo dinh dưỡng, bị nhiễm mặn, thực vật sống được. Trên các diện tích trồng cây rất hạn hẹp, chưa đủ đáp ứng nhu cầu rau xanh, trong khi mở rộng ngày càng lớn. Do đó cải tạo thành canh tác Trong nghiên cứu này, chúng tôi đã tuyển chọn được 7 chủng vi khuẩn nguồn gốc từ khả năng chịu mặn và sinh exopolysaccharide (EPS). Vi EPS biết đến với nước dưỡng cho...
La synthese du glycogene hepatique et des acides gras est augmentee par certains amines (glutamine, alanine, proline). Le mecanisme de cette stimulation fait intervenir le gonflement l'hepatocyte a la suite co-transport l'acide amine Na + . diminution volume compensatoire se sortie K Cl - accompagnes d'eau. Il en resulte une augmentation concentration cellulaire glutamate d'aspartate reduction celle Or l'aspartate sont activateurs synthase l'acetyl-CoA carboxylase, deux enzymes cles...