A5104294007- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Gene expression and cancer classification
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Cancer Genomics and Diagnostics
Linköping University
2023-2025
Science for Life Laboratory
2025
Gene regulators physically associate to the genome, in a combinatorial fashion, drive tissue-specific gene expression. Uncovering genome-wide activity of all across tissues is therefore needed understand regulation during development. Here, we take first step towards this goal. Using CUT&RUN, systematically mapped binding profiles key transcription factors and cofactors that mediate ontogenetically relevant signaling pathways select mouse at two developmental stages. Computation datasets...
Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action nuclear β-catenin. Yet, little is known about how β-catenin generates context-specific transcriptional outcomes. Understanding this will reveal aberrant Wnt/β-catenin causes neoplasia specifically colorectal epithelium. We have previously identified transcription factor TBX3 as tissue-specific component complex mouse forelimb development. In study, we show that...
Abstract Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action nuclear β-catenin. Furthermore, neoplasia colorectal epithelium begins with aberrant Wnt/β-catenin signaling. Yet, little is known about how β-catenin generates context-specific transcriptional outcomes. We have previously identified developmental transcription factor TBX3 as tissue-specific component complex mouse forelimb development. In this study, we...
Abstract The identification of regulatory networks contributing to fetal/adult gene expression switches is a major challenge in developmental biology and key understand the aberrant proliferation cancer cells, which often reactivate fetal oncogenes. One example represented by LIN28B , whose reactivation adult tissues promotes tumor initiation progression. Despite prominent role development cancer, mechanisms its transcriptional regulation are largely unknown. Here, using quantitative RT-PCR...
Activity of central amygdala (CeA) PKCδ expressing neurons has been linked to appetite regulation, anxiety-like behaviors, pain sensitivity, and addiction-related behaviors. Studies the role that CeA PKCδ+ play in these behaviors have largely carried out mice, genetic tools would allow selective manipulation cells rats lacking. Here, we used a CRISPR/Cas9 strategy generate transgenic
Gene regulators physically associate to the genome, in a combinatorial fashion, drive tissue-specific gene expression programs. Uncovering genome-wide activity of all across tissues is therefore needed understand how genome regulated during development. Here, we take first step forward towards achieving this goal. Using CUT&RUN, systematically measured binding profiles key transcription factors and cofactors that mediate ontogenetically relevant signaling pathways select mouse at two...