A5035795280- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Renal and related cancers
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Université Libre de Bruxelles
2023-2025
Universitair Ziekenhuis Brussel
2020
Thyroid cancer is the most prevalent endocrine malignancy, and papillary thyroid carcinoma (PTC) common type of malignancy. While PTC generally has a favorable prognosis, subset dedifferentiates into aggressive forms. However, molecular mechanisms responsible for aggressiveness dedifferentiation are still poorly understood. We previously showed that HMGA2, non-histone architectural transcription factor overexpressed in PTC, involved cell invasion. This study aimed to further analyze role...
Thyroid cancer is the most common endocrine malignant tumor with an increasing incidence rate. Although differentiated types of thyroid generally present good clinical outcomes, some dedifferentiate into aggressive and lethal forms. However, molecular mechanisms governing aggressiveness dedifferentiation are still poorly understood. Aberrant expression miRNAs often correlated to development, miR-204-5p has previously been identified in papillary carcinoma as downregulated associated...
With the improvement of treatment methods in acute hematology malignancies, development sensitive tools for minimal residual disease assessment has become a priority. The monitoring WT1 expression level by real-time quantitative PCR been standard evaluation myeloid leukemia and, since 2009, optimized through European LeukemiaNet effort an established protocol with well-defined clinical end points. Building on work LeukemiaNet, this article reports novel, one-step duplex WT1/ABL1 droplet...