A5107693957- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Plant Gene Expression Analysis
- Alzheimer's disease research and treatments
Institute for Neurodegenerative Disorders
2024
University of Pittsburgh
2024
Oxidative stress has long been implicated in Parkinson’s disease (PD) pathogenesis, although the sources and regulation of reactive oxygen species (ROS) production are poorly defined. Pathogenic mutations gene encoding leucine-rich repeat kinase 2 (LRRK2) associated with increased activity a greater risk PD. The substrates downstream consequences elevated LRRK2 still being elucidated, but overexpression mutant oxidative stress, antioxidants reportedly mitigate toxicity. Here, using...
Pesticide exposure is increasingly recognised as a potential environmental factor contributing to the onset of idiopathic Parkinson's disease, yet molecular mechanisms underlying this connection remain unclear. This study aims explore how pesticide disrupts key brain regions involved in disease pathology by reshaping gene regulatory landscapes. Using well-established rotenone rat model we performed H3K27ac ChIP-sequencing profile active elements substantia nigra and cortex. In model,...