A5090886070- Microbial Natural Products and Biosynthesis
- Computational Drug Discovery Methods
- Microbial Metabolism and Applications
- African Botany and Ecology Studies
- Phytochemicals and Antioxidant Activities
- Phytochemical Studies and Bioactivities
- Genomics and Phylogenetic Studies
- Ethnobotanical and Medicinal Plants Studies
- Agricultural and Food Sciences
- Genetics, Bioinformatics, and Biomedical Research
- Mangiferin and Mango Extracts
Universidad San Ignacio de Loyola
2024
University of Buea
2016-2020
Natural products (NPs) are often regarded as sources of drugs or drug leads simply a "source inspiration" for the discovery novel drugs. We have built Northern African Products Database (NANPDB) by collecting information on ∼4500 NPs, covering literature data period from 1962 to 2016. The cover compounds isolated mainly plants, with contributions some endophyte, animal (e.g., coral), fungal, and bacterial sources. were identified 617 source species, belonging 146 families. Computed...
Abstract Antimicrobial resistance is an emerging global health threat necessitating the rapid development of novel antimicrobials. Remarkably, vast majority currently available antibiotics are natural products (NPs) isolated from streptomycetes, soil-dwelling bacteria genus Streptomyces. However, there still a huge reservoir streptomycetes NPs which remains pharmaceutically untapped and compendium thereof could serve as source inspiration for rational design antibiotics. Initially released...
Streptomycetes remain an important bacterial source of natural products (NPs) with significant therapeutic promise, particularly in the fight against antimicrobial resistance. Herein, we present StreptomeDB 4.0, a substantial update database that includes expanded content and several new features. Currently, 4.0 contains over 8500 NPs originating from ∼3900 streptomycetes, manually annotated ∼7600 PubMed-indexed peer-reviewed articles. The was enhanced by two in-house developments: (i)...
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