A5060485807- Crystal Structures and Properties
- S100 Proteins and Annexins
- Catalysis and Oxidation Reactions
- Inorganic Fluorides and Related Compounds
- Protease and Inhibitor Mechanisms
- Inorganic Chemistry and Materials
- Catalytic Processes in Materials Science
- Traumatic Brain Injury and Neurovascular Disturbances
- Machine Learning in Bioinformatics
- Alzheimer's disease research and treatments
- Advanced Condensed Matter Physics
- Dementia and Cognitive Impairment Research
- Advanced Proteomics Techniques and Applications
- Gas Sensing Nanomaterials and Sensors
- RNA modifications and cancer
- Chemical Synthesis and Characterization
- Genetic factors in colorectal cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Connexins and lens biology
- Polyoxometalates: Synthesis and Applications
- Gut microbiota and health
- Iron-based superconductors research
- Neonatal Respiratory Health Research
- RNA and protein synthesis mechanisms
- Sepsis Diagnosis and Treatment
University of Münster
1998-2000
Kiel University
1994
Abstract Biomarkers are needed to elucidate the biological background and improve detection of cancer. Therefore, we have analyzed laser-microdissected cryostat sections from head neck tumors adjacent mucosa on ProteinChip arrays. Two differentially expressed proteins (P = 3.34 × 10−5 4.6 10−5) were isolated by two-dimensional gel electrophoresis identified as S100A8 (calgranulin A) S100A9 B) in-gel proteolytic digestion, peptide mapping, tandem mass spectrometry analysis, immunodepletion...
We investigated protein profiles obtained from colorectal tumor tissue and adjacent normal mucosa to identify specific changes. Protein extracts of biopsis were separated by two-dimensional gel electrophoresis >40 low-molecular mass proteins identified peptide fingerprinting using surface-enhanced laser desoption/ionization spectrometry (SELDI-MS). Among these, PACAP protein, hnrnp A1, flavin reductase, calgizzarin, NDK B (NM23-H2), cyclophilin A smooth muscle 22-alpha showed significantly...
Early differential diagnosis of systemic inflammatory reactions in critically ill patients is essential for timely implementation lifesaving therapies. Despite many efforts made, reliable biomarkers to discriminate between infectious and noninfectious causes response syndrome (SIRS) are currently not available. Recent advances mass spectrometry-based methods have raised hopes that identification spectral patterns from serum/plasma samples can be instrumental this context. We compared protein...
The ratio of amyloid precursor protein (APP)669–711 (Aβ−3–40)/Aβ1–42 in blood plasma was reported to represent a novel Alzheimer’s disease biomarker. Here, we describe the characterization two antibodies against N-terminus Aβ−3–x and development “fit-for-purpose” technical validation sandwich immunoassay for measurement Aβ−3–40. Antibody selectivity assessed by capillary isoelectric focusing immunoassay, Western blot analysis, immunohistochemistry. analytical addressed assay range,...
Abstract The Aβ42/40 ratio and the concentration of phosphorylated Tau181 in blood plasma represent attractive biomarkers for Alzheimer's disease. As a means reducing potential matrix effects, which may interfere with immunoassays, we have previously developed pre-analytical sample workup by semi-automated immunoprecipitation. Here test compatibility immunoprecipitations automated Aβ1-40, Aβ1-42 immunoassays on Lumipulse platform compare diagnostic performance respective immunoprecipitation...
Abstract Background Measurements of the amyloid-β (Aβ) 42/40 ratio in blood plasma may support early diagnosis Alzheimer’s disease and aid selection suitable participants clinical trials. Here, we compared diagnostic performance fully automated prototype Aβ42/40 assays with without pre-analytical sample workup by immunoprecipitation. Methods A pre-selected comprising 42 subjects normal 38 low cerebrospinal fluid (CSF) ratios was studied. The were determined Elecsys® immunoassays (Roche...
SrCo 2 V O 8 (I) and (As0 4 ) (II) were prepared by crystallization from melts investigated X-ray single crystal technique. is isotypic to the SrNi -type crystallizes with tetragonal symmetry, space group C 12 v-I4 1 cd, a = 12.267: c 8.424 Å: Z 8. lately found (PO , i -P1̅, 5.713; b 6.903; 9.417 110.48; β 101.43; γ 99.13°, 2.
Annexins are Ca2+-regulated membrane binding proteins implicated in a wide range of membrane-related and signal transduction events, including the endocytosis receptors as well constitutive secretion. To date, 10 unique members this multigene family have been identified variety cell types tissues higher vertebrates, with different showing distinct tissue distributions adult organisms. establish whether annexins also function embryonic development, we analyzed expression pattern during...
Abstract Mit CO 2 ‐LASER‐Technik wurden bei ca. 1 000°C Einkristalle der Verbindung BaCu (AsO 4 ) dargestellt und röntgenographisch untersucht. Die blaßblauen Kristalle haben monokline Symmetrie, Raumgruppe C P2 /n, mit a = 4,752; b 8,506; c 8,945 Å; β 93,49°, Z 2. repräsentiert einen neuen Strukturtyp, Cu 2+ in trigonal bipyramidaler Koordination zeigt. Ba ist 8 + 2‐fach As 5+ tetraedrisch von Sauerstoff umgeben. Kristallstruktur wird unter Bezug auf verwandte Orthophosphate ‐vanadate diskutiert.
Single crystals of Cu(Mg 2 . 56 Cu 0.44 )Cu(AsO 4 ) 3 have been prepared by CO -LASER technique and investigated X-ray diffraction methods. The light blue show monoclinic symmetry, space group C 6 2h -C2/c, a = 11.897, b 12.855, c 6.688 Å, β 113.06°, Z 4. structure type is characterized AsO tetrahedra, dumb-bell-like coordinated Cu(I), twisted CuO square polygons octahedra statistically occupied Mg/Cu 2+
Abstract Einkristalle von Co 5 AsVO 10 wurden durch Feststoffreaktionen erhalten und röntgenographisch untersucht. Diese Verbindung kristallisiert mit monokliner Symmetrie, Raumgruppe C –C2/m; a = 19,134; b 6,095; c 17,482 Å; β 133,37°; Z 8. Der neue Strukturtyp ist CoO 6 ‐ AsO ‐Oktaederschichten ausgezeichnet, die teilweise alternierend 2+ As 5+ besetzt sind. Die Oktaederschichten werden in tetraedrischer Koordination statistisch V besetzte Punktlagen verknüpft.