A5053302978- Advanced NMR Techniques and Applications
- Protein Structure and Dynamics
- NMR spectroscopy and applications
- Enzyme Structure and Function
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Antifungal resistance and susceptibility
- RNA Research and Splicing
- biodegradable polymer synthesis and properties
- Piperaceae Chemical and Biological Studies
- Microbial metabolism and enzyme function
- Conducting polymers and applications
- Amino Acid Enzymes and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Neuroimaging Techniques and Applications
- Hydrogels: synthesis, properties, applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Battery Materials and Technologies
Yale University
2018-2024
University of Illinois Urbana-Champaign
2014-2016
Gold nanoparticles (Au NPs) have attracted much attention due to their potential applications in nano-medicine. While numerous studies quantified biomolecular adsorption Au NPs terms of equilibrium binding constants, far less is known about orientation on nanoparticle surfaces. In this study, the protein α-synuclein citrate and (16-mercaptohexadecyl) trimethylammonium bromide (MTAB) coated 12 nm examined by heteronuclear single quantum coherence NMR spectroscopy provide site-specific...
The function of a protein is predicated upon its three dimensional fold. Representing complex structure as series repeating secondary structural elements one the most useful ways by which we study, characterize, and visualize protein. Consequently, experimental methods that quantify content allow us to connect protein’s function. Here, introduce an automated gradient descent-based method refer Secondary Structure Distribution NMR allows for rapid quantification composition from single, 1D...
The function of a protein is predicated upon its three-dimensional fold. Representing complex structure as series repeating secondary structural elements one the most useful ways by which we study, characterize, and visualize protein. Consequently, experimental methods that quantify content allow us to connect protein's function. Here, introduce an automated gradient descent-based method refer secondary-structure distribution NMR allows for rapid quantification composition from single, 1D
Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins has been associated with neurodegenerative diseases, although direct mechanisms are poorly defined. Here, we report on a maturation process for the cellular prion protein (PrP