Ruby Redlich
A5077859085- Genetic diversity and population structure
- Evolution and Paleontology Studies
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Bat Biology and Ecology Studies
- Animal Vocal Communication and Behavior
- Physiological and biochemical adaptations
- Marine animal studies overview
Carnegie Mellon University
2023-2024
University of Pittsburgh
2023
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes 240 species, we identify bases that, when mutated, are likely affect fitness and alter disease risk. At least 332 million (~10.7%) in human genome unusually conserved across species (evolutionarily constrained) relative neutrally evolving repeats, 4552 ultraconserved elements nearly perfectly conserved. Of 101 significantly constrained single bases, 80% outside protein-coding exons half...
Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from the Egyptian fruit bat (
Abstract Evolutionary constraint and acceleration are powerful, cell-type agnostic measures of functional importance. Previous studies in mammals were limited by species number reliance on human-referenced alignments. We explore the evolution placental mammals, including humans, through reference-free whole-genome alignment 240 protein-coding alignments for 428 species. estimate 10.7% human genome is evolutionarily constrained. resolve to single nucleotides, pinpointing positions, refine...
Abstract Comparative genomics approaches seek to associate evolutionary genetic changes with the evolution of phenotypes across a phylogeny. Many these methods, including our rates based method, RERconverge, lack capability analyzing non-ordinal, multicategorical traits. To address this limitation, we introduce an expansion RERconverge that associates shifts in convergent multi-categorical The categorical includes methods for performing ancestral state reconstruction, statistical tests...
Comparative genomics approaches seek to associate molecular evolution with the of phenotypes across a phylogeny. Many these methods lack ability analyze non-ordinal categorical traits more than two categories. To address this limitation, we introduce an expansion RERconverge that associates shifts in evolutionary rates convergent traits. The includes for performing ancestral state reconstruction, statistical tests associating relative variables, and new method phylogeny-aware permutations,...