Login

Simona Serra

ORCID: 0009-0003-1170-3158
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
A5103030853
Research Areas
  • Pneumonia and Respiratory Infections
  • Bacterial Infections and Vaccines
  • Ion channel regulation and function
  • Streptococcal Infections and Treatments

Karolinska Institutet
 2023-2024

 The single D380 amino acid substitution increases pneumolysin cytotoxicity toward neuronal cells
OPENALEX - Publications 
Simona Serra Vittorio Iannotti Margherita Ferrante Miguel Tofiño-Vian Joseph Baxendale and 5 more Gilad Silberberg Thomas P. Kohler Sven Hammerschmidt Andrew T. Ulijasz Federico Iovino

Bacterial meningitis, frequently caused by

10.1016/j.isci.2024.109583 article EN cc-by iScience 2024-03-27
 A Single Amino Acid Substitution in the D4 Domain Enhances the Pore-Forming Activity and Cytotoxic Power of Pneumolysin in Streptococcus pneumoniae
OPENALEX - Publications 
Simona Serra Vittorio Iannotti Margherita Ferrante Miguel Tofiño-Vian Thomas P. Kohler and 3 more Sven Hammerschmidt Andrew T. Ulijasz Federico Iovino

Bacterial meningitis, frequently caused by Streptococcus pneumoniae (the pneumococcus), is a major cause of permanent neurological disorders such as cognitive delay, motor disabilities, and hearing loss, which are due to neuronal damage the infection. Pneumolysin (PLY), cholesterol-binding toxin that, once released in host environment, can variety eukaryotic cells, including neurons, through its pore-forming activity. Interestingly, we observed that pneumococcal meningitis clinical isolates...

10.2139/ssrn.4677546 preprint EN 2023-01-01
Coming Soon ...