A5068092690- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Chemical Reactions and Isotopes
- Lanthanide and Transition Metal Complexes
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Click Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Advanced Breast Cancer Therapies
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- Lung Cancer Treatments and Mutations
- Barrier Structure and Function Studies
- Fluorine in Organic Chemistry
- Genetic Neurodegenerative Diseases
- Visual perception and processing mechanisms
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Face Recognition and Perception
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience of respiration and sleep
- Neural dynamics and brain function
- Epilepsy research and treatment
National Heart Lung and Blood Institute
2012-2025
Chinese Institute for Brain Research
2024
Beijing Institute of Education
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Nantong University
2024
National Institutes of Health
2008-2023
University of Maryland, Baltimore
2007-2014
Brookhaven National Laboratory
2005-2006
Increased brain levels of the tryptophan metabolite kynurenic acid (KYNA) have been linked to cognitive dysfunctions in schizophrenia and other psychiatric diseases. In rat, local inhibition kynurenine aminotransferase II (KAT II), enzyme responsible for neosynthesis readily mobilizable KYNA brain, leads a prompt reduction extracellular levels, secondarily induces an increase glutamate, dopamine, acetylcholine several areas. Using microdialysis unanesthetized, adult rats, we now show that...
Abstract The oncoprotein MYCN drives malignancy in various cancer types, including neuroblastoma (NB). However, our understanding of the mechanisms underlying its transcriptional activity and oncogenic function, as well effective strategies to target it, remains limited. We discovered that interacts with coactivator KAT2A, this interaction significantly contributes MYCN’s NB. Our genome-wide analyses indicate recruits KAT2A bind DNA, thereby transcriptionally regulating genes associated...
The primate brain is equipped to learn and remember newly encountered visual stimuli such as faces objects. In the macaque inferior temporal (IT) cortex, neurons mark familiarity of a stimulus through response modification, often involving decrease in spiking rate. Here, we investigate emergence this neural plasticity by longitudinally tracking IT during several weeks familiarization with face images. We found that most anterior medial (AM) patch exhibited gradual decline their late-phase...
A known selective agonist of the A(3) adenosine receptors (AR), MRS1898 [(1'R,2'R,3'S,4'R,5'S)-4-{2-chloro-6-[(3-iodophenylmethyl)amino]purin-9-yl}-1-(methylaminocarbonyl)bicyclo[3.1.0]hexane-2,3-diol], was synthesized in radioactive form and characterized pharmacologically. This ligand series, based on nucleoside analogues containing a rigid, bicyclic ring system place ribose moiety, selected for radiolabeling due to its high A(3)AR affinity across species, with nanomolar binding at both...
Advances in drug treatments for brain metastases of breast cancer have improved progression-free survival but new, more efficacious strategies are needed. Most chemotherapeutic drugs infiltrate by moving between capillary endothelial cells, paracellular distribution, resulting heterogeneous lower than that systemic metastases. Herein, we tested three well-known transcytotic pathways through cells as potential avenues access: transferrin receptor (TfR) peptide, low-density lipoprotein 1...
<p>Supplementary Material and Methods</p>
<p>Supplementary Figures S1-S10</p>
<div>Abstract<p>Advances in drug treatments for brain metastases of breast cancer have improved progression free survival but new, more efficacious strategies are needed. Most chemotherapeutic drugs infiltrate by moving between capillary endothelial cells, paracellular distribution, resulting heterogeneous lower than that systemic metastases. Herein, we tested three well-known transcytotic pathways through cells as potential avenues access: Transferrin receptor (TfR) peptide, Low...
<p>Supplementary Figures S1-S10</p>
<p>Supplementary Material and Methods</p>
<div>Abstract<p>Advances in drug treatments for brain metastases of breast cancer have improved progression-free survival but new, more efficacious strategies are needed. Most chemotherapeutic drugs infiltrate by moving between capillary endothelial cells, paracellular distribution, resulting heterogeneous lower than that systemic metastases. Herein, we tested three well-known transcytotic pathways through cells as potential avenues access: transferrin receptor (TfR) peptide,...
<p>Supplementary Figures S1-S10</p>
<p>Supplementary Material and Methods</p>
<p>Supplementary Material and Methods</p>
<p>Supplementary Figures S1-S10</p>