A5003615480- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Natural Compounds in Disease Treatment
- Hepatitis B Virus Studies
- Connexins and lens biology
- Hepatitis C virus research
- Galectins and Cancer Biology
- Histone Deacetylase Inhibitors Research
- Cell death mechanisms and regulation
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Telomeres, Telomerase, and Senescence
- Heat shock proteins research
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Folate and B Vitamins Research
Chinese University of Hong Kong
2024
Nanyang Technological University
2023-2024
Binzhou People's Hospital
2020
Nanjing University
2013-2014
Abstract We introduce MolPhase, an advanced algorithm for predicting protein phase separation (PS) behavior that improves accuracy and reliability by utilizing diverse physicochemical features extensive experimental datasets. MolPhase applies a user-friendly interface to compare distinct biophysical side-by-side along sequences. By additional comparison with structural predictions, enables efficient predictions of new phase-separating proteins guides hypothesis generation design. Key...
Urokinase (uPA) and its receptor (uPAR) play an important role in tumour growth metastasis, overexpression of these molecules is strongly correlated with poor prognosis a variety malignant tumours. Targeting the excessive activation this system as well proliferation vascular endothelial cell would be expected to prevent neovasculature halt development. The amino terminal fragment (ATF) urokinase has been confirmed effective inhibit proliferation, migration invasiveness cancer cells via...
Abstract Background The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR heat shock proteins HSP70 MRJ (DNAJB6) have been implicated in tumor growth metastasis. We reported recently that (DNAJB6, a protein) can interact with enhance adhesion. Here, we identified another protein as novel uPAR-interacting protein. Methods performed co-immunoprecipitation human embryonic kidney (HEK) 293 colon...
Abstract We introduce MolPhase ( http://molphase.sbs.ntu.edu.sg/ ), an advanced protein phase separation (PS) prediction algorithm that improves accuracy and reliability by utilizing diverse physicochemical features extensive experimental datasets. applies a user-friendly interface to compare distinct biophysical side-by-side along sequences. By additional comparison with structural predictions, enables efficient predictions of new phase-separating proteins guides hypothesis generation...