A5018113592- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Colorectal and Anal Carcinomas
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- S100 Proteins and Annexins
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Urban Green Space and Health
- Epigenetics and DNA Methylation
- Teratomas and Epidermoid Cysts
- Surgical site infection prevention
- Developmental Biology and Gene Regulation
- Olfactory and Sensory Function Studies
- Medical Image Segmentation Techniques
- Macrophage Migration Inhibitory Factor
China Medical University
2018-2024
Liaoning Cancer Hospital & Institute
2012-2023
Sheng Jing Hospital
2020-2021
Epizyme (United States)
2021
Gangwon State University
2012
Huaqiao University
2008
Veterans Biomedical Research Institute
1996
Immunohistochemical methods were used to search for Fas receptor/Fas ligand system involvement in multiple sclerosis (MS) white matter brain lesions. We found large numbers of (Fas-L)-bearing cells present two acute lesions and 12 16 chronic MS lesions, very few positive non-inflammatory controls. Four six brains from non-MS neuropathologic conditions associated with inflammation disease were, however, also Fas-L. Double staining cell-specific markers revealed that the pattern...
Abstract Background Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for majority of skin-cancer-related deaths. Despite great development and evolution have been made in surgery, radiotherapy adjuvant chemotherapy, prognosis melanoma patients exhibited no significant improvement. Long noncoding RNAs (lncRNAs) are frequently dysregulated involved cancers. LncRNA AFAP1-AS1 has explored various cancers, whereas its role regulatory mechanism not well...
Osteosarcoma is one of the bone malignancies in children and adolescents. Long noncoding RNAs (lncRNAs) have been demonstrated to participate osteosarcoma development progression. Linc00265 has shown involve oncogenesis; however, underlying mechanism largely unclear. In this study, we investigated function linc00265 cells, including cell viability, migration invasion. Moreover, elucidated mechanistically involvement osteosarcoma. We found that overexpression promoted invasion cells. Notably,...
Osteosarcoma, the most common bone malignancy in children and adolescents, poses considerable challenges terms of prognosis, especially for patients with metastatic or recurrent disease. While surgical intervention adjuvant chemotherapy have improved survival rates, limitations such as impractical tumor removal resistance hinder treatment outcomes. Chimeric antigen receptor (CAR)-T cell therapy, an innovative immunotherapy approach that involves targeting antigens releasing immune factors,...
Osteosarcoma is a common type of bone cancer characterized by poor prognosis due to its metastatic nature. The tumor microenvironment (TME) plays critical role in metastasis and therapy response. Therefore, our study aims explore the mechanism osteosarcoma, potentially opening new avenues for treatment.
Abstract Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the tyrosine kinase/insulin receptor family. facilitates progression various malignancies via self‐mutations or rearrangements. Studies on ROS1‐directed kinase inhibitors have been conducted, and some approved by FDA for clinical use. However, adverse effects mechanisms resistance associated with remain unknown. In addition, next‐generation inhibitors, which advantage treating central nervous system...
The molecular mechanism of osteosarcoma (OS) pathogenesis is poorly understood. Notch signaling pathway has been shown to be critically involved in tumorigenesis, including OS. Therefore, we explored the by which Notch-1 OS progression. Several approaches were carried out determine biological function cells. MTT results revealed that overexpression increased viability cells, whereas downregulation reduced cell viability. Consistently, modulation regulated apoptosis and migratory invasive...
Background: Osteosarcoma (OS) is the most common primary malignant bone tumor. Hence, there an urgent need to identify effective and safe therapeutic agents against OS. It has been reported that Ilex hainanensis Merr (IME) possesses antitumor properties. Integrin subunit alpha V (ITGAV) important for diagnosis, treatment, prognosis of tumors. Purpose: The objective this study was whether IME can play a role in treatment osteosarcoma by regulating ITGAV. Methods: Western blot real-time PCR...
Osteosarcoma is a highly malignant tumour that occurs in adolescents. Upregulation or the constitutive activation of epidermal growth factor receptor (EGFR) hallmark osteosarcoma. To investigate effect ursolic acid on biological function osteosarcoma, MTT assay was used to detect proliferation HOS and MG63 cells, while flow cytometry analyse cell cycle apoptosis. Transwell Matrigel assays were migration invasion, respectively. Western blot analysis reverse transcription‑quantitative...
The pelvic structure is complex and the tumor poorly defined from surrounding tissues. Finding exact resection margin based on surgeon's clinical experience alone a time-consuming difficult task, which major factor leading to surgical failure. An accurate method for segmenting bone tumors needed. In this paper, semiautomatic segmentation CT-MR multimodal images presented. combines multiple medical prior knowledge image algorithms. Finally, results are visualized in three dimensions. We...
Abstract Objective Osteosarcoma is a rare primary malignant tumor of the bone characterized by poor survival rates, owing to its unclear pathogenesis. Rho GTPase-activating protein 44 ( ARHGAP44 ), which belongs family, has promising applications in targeted therapy tumors. Therefore, this study aimed investigate biological function osteosarcoma and possible application as therapeutic target. Methods The expression level relationship with prognosis were detected using Gene Expression Omnibus...
Teratomas are rare neoplasms that arise from pluripotent germ cells. Sacrococcygeal teratomas often diagnosed in infants but adults; a mature teratoma can contain hair, teeth, bony tissue, and other tissue types. Herein, we report for the first time patient with containing intact bones formed pseudoarthrosis. A 49-year-old woman was admitted to hospital after massive life-long sciatic tumor had begun grow larger over past year. 16 cm × 25 solid mass clear boundary palpable sacrococcygeal...