A5041933986- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Systemic Lupus Erythematosus Research
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Cellular Mechanics and Interactions
- Mast cells and histamine
- Bone and Joint Diseases
- CNS Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Electrolyte and hormonal disorders
- Blood properties and coagulation
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
Rigshospitalet
2017-2025
Copenhagen University Hospital
2019-2024
University of Copenhagen
2010-2019
Zealand University Hospital
2016
Herlev Hospital
2009-2016
Capital Region of Denmark
2011-2015
Gentofte Hospital
2011-2015
Roskilde Sygehus
2015
Odense University Hospital
2006-2007
University of Southern Denmark
2006-2007
Gene expression profiling studies have unraveled deregulation of several genes that might be pathogenetic importance for the development and phenotype Philadelphia-negative chronic myeloproliferative neoplasms. In context interferon-alpha2 as a promising therapeutic agent, we focused upon transcriptional interferon-associated in patients with essential thrombocythemia (ET) (n = 19), polycythemia vera (PV) 41), primary myelofibrosis (PMF) 9). Using whole-blood accordingly obtaining an...
Essential thrombocythemia (ET) and polycythemia vera (PV) are Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPNs) characterized by the JAK2 V617F mutation, which can be found in more than 98% of PV patients ∼ 50% ET patients. Assessment allele burden a highly sensitive quantitative PCR (qPCR) assay appears to useful tool for monitoring minimal residual disease (MRD) evaluating treatment efficacy. This report expands substantiates existing data, showing that...
Myeloproliferation, myeloaccumulation (decreased apoptosis), inflammation, bone marrow fibrosis and angiogenesis are cardinal features of the Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) primary myelofibrosis (PMF). Histone deacetylases (HDACs) have a critical role in modulating gene expression and, accordingly, control cell pathobiology cancer development. HDAC inhibition has been shown to inhibit tumor growth (impaired...
Abstract In recent years, major molecular remissions have been observed in patients with JAK 2‐positive chronic myeloproliferative neoplasms ( MPN s) after therapy IFN ‐ α . is known to altering effects on immune cells involved surveillance and might consequently enhance anti‐tumor response against the 2‐mutated clone. The objective of this study was investigate circulating levels phenotype natural killer 29 during treatment. Furthermore, functional studies NK upon target‐cell recognition...
Gene expression profiling studies in the Philadelphia-negative chronic myeloproliferative neoplasms have revealed significant deregulation of several immune and inflammation genes that might be importance for clonal evolution due to defective tumor surveillance. Other mechanisms down-regulation major histocompatibility (MHC) class I II genes, which are used by cells escape antitumor T-cell-mediated responses. We performed whole blood transcriptional encoding human leukocyte antigen (HLA)...
Abstract Mutations in exon 9 of the calreticulin gene ( CALR ) frequently occur patients with chronic myeloproliferative neoplasms (MPN). Patients exhibit spontaneous cellular immune responses to epitopes derived from mutant C-terminus, and -mutant-specific T cells recognize autologous -mutant malignant cells. This study investigated whether naturally wt MPN-patients healthy individuals. Specific against peptide sequence were detected both Healthy donors displayed more frequent stronger...
Long-term therapy with IFN-α2 is associated sustained major molecular remissions in JAK2-positive ET and PV. The efficacy of may be partly mediated by modulation immune cells, which was investigated twenty patients (n = 6) PV 14). frequency CD4(+) CD25(+) Foxp3(+) T cells significantly increased during treatment all (P < 0.0001). A significant expansion the CD56(bright) NK 0.0002) a concomitant decrease CD56(dim) 0.0001) were also detected. Myeloid DCs (mDCs) plasmacytoid (pDCs) studied nine...
The Chronic Myeloproliferative Neoplasms (MPN) are cancers characterized by hyperinflammation and immune deregulation. Concurrently, the expression of check point programmed death ligand 1 (PD-L1) is induced inflammation. In this study we report on occurrence spontaneous T cell responses against a PD-L1 derived epitope in patients with MPN. We show that 71% display significant response PD-L1, advanced MPN have significantly fewer weaker specific compared to non-advanced CD4+ responses, gene...
e19014 Background: Low expectations of clinical benefit from Phase I cancer trials may hinder patient participation and delay study findings. Although progress in drug development, shifting cytotoxic agents to targeted therapies immunotherapies, have improved treatment responses, comprehensive data remain limited. This aims evaluate outcomes for solid tumors hematological malignancies trials. Methods: Between 2018 2020, a total 231 patients with advanced were enrolled trial at the Unit,...
Recent studies have shown that a large proportion of patients classified as essential thrombocythemia (ET) actually early primary prefibrotic myelofibrosis (prePMF), which implies an inferior prognosis compared to being diagnosed with so-called genuine or true ET. According the World Health Organization (WHO) 2008 classification, bone marrow histology is major component in distinction between these disease entities. However, differential diagnosis them may be challenging and several not been...