A5074887037- Neuroscience and Neuropharmacology Research
- Color perception and design
- Electrospun Nanofibers in Biomedical Applications
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
Keck Hospital of USC
2025
University of California, Irvine
2024
The University of Texas at San Antonio
2017
Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue repair. This study investigates how crosslinking of gelatin-based hydrogels influences immune and stromal cell behavior healing in female mice. We observe that softer, lightly crosslinked promote greater cellular infiltration result smaller scars compared stiffer, heavily hydrogels. Using single-cell RNA sequencing, we further show increase inflammation lead the formation a distinct macrophage...
Despite increased neuronal death, senile plaques, and neurofibrillary tangles observed in patients suffering from Alzheimer's disease (AD), the detailed mechanism of cell death AD is still poorly understood.We hypothesized that p38 kinase activates then phosphorylates Bax, leading to its translocation mitochondria brains compared controls. The aim this study was investigate role phosphorylation sub-cellular localization pro-apoptotic Bax frontal cortex control subjects. Increased oxidative...