A5090283711- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Enzyme Structure and Function
- Cancer Treatment and Pharmacology
- Erythrocyte Function and Pathophysiology
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Ethics in Clinical Research
- Bacterial Genetics and Biotechnology
- Protein purification and stability
- Biochemical and Molecular Research
- Clinical practice guidelines implementation
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
Dana-Farber Cancer Institute
2023-2024
University of Florida
2024
University of Washington
2011-2012
Center for Infectious Disease Research
2012
Joint Center for Structural Genomics
2011
Insoluble recombinant proteins are a major issue for both structural genomics and enzymology research. Greater than 30% of expressed in Escherichia coli (E. coli) appear to be insoluble. The prevailing view is that insolubly cannot easily solubilized, usually sequestered into inclusion bodies. However, we hypothesize small molecules added during the cell lysis stage can yield soluble protein from insoluble previously screened without additives or ligands. We present novel screening method...
Abstract As a treatment for relapsed or refractory multiple myeloma (MM), carfilzomib has been associated with significant risk of cardiovascular adverse events (CVAE). The goals our study were to evaluate the metabolomic profile MM patients identify those at high prior and explore mechanisms carfilzomib‐CVAE inform potential strategies protect from this cardiotoxicity. Global profiling was performed on baseline post‐baseline plasma samples 60 treated carfilzomib‐based therapy, including 31...
Cryptosporidium parvum is one of several spp. that cause the parasitic infection cryptosporidiosis. Cryptosporidiosis a diarrheal spread via fecal–oral route and commonly caused by contaminated drinking water. Triosephosphate isomerase an enzyme ubiquitous to all organisms perform glycolysis. catalyzes formation glyceraldehyde 3-phosphate from dihydroxyacetone phosphate, which critical step ensure maximum ATP production per glucose molecule. In this paper, 1.55 Å resolution crystal structure...
414 Background: Fewer than 10% of adult cancer patients participate in clinical trials. Clinical pathways platforms have traditionally sought to improve trial accrual by displaying available trials for eligible patients. Our team explored how Pathways navigation data can also be used identify poorly accruing and provide study investigators with a near real-time feed those Methods: Providers at Dana-Farber Cancer Institute are asked navigate the decision-support platform order systemic...
415 Background: Oral targeted therapies in lung cancer represent a costly but critical component of care. Currently, the approval process for these treatments can sometimes take several weeks. Assessing rates and efficacy on-pathway treatment recommendations is an important step towards bringing clinicians payors together to streamline decision support authorization process. Methods: We retrospectively analyzed requests oral anti-cancer agents cancer. Eligible were filed between August 1,...
492 Background: Dana-Farber Cancer Institute’s (DFCI) Clinical Pathways provide evidence-based decision support for oncologists across a variety of care settings. Data generated by enable continued cancer improvement and may also be tool identifying patient candidates survivorship. Here, we explore patients diagnosed with testicular treated curative intent. Methods: Oncologists at DFCI navigate when starting or changing therapies. Each navigation provides discrete clinical data elements...