A5116035341- Digestive system and related health
- Mechanisms of cancer metastasis
Center for Systems Biology
2025
Harvard University
2025
In pancreatic ductal adenocarcinoma cancer (PDAC) drug resistance is a severe clinical problem and patients relapse within few months after receiving the standard-of-care chemotherapy. One contributing factor to treatment desmoplastic nature of PDAC; tumours are surrounded by thick layers stroma composing up 90% tumour mass. This stroma, which mostly comprised extracellular matrix (ECM) proteins, secreted cancer-associated fibroblasts (CAFs) residing in microenvironment. However, mechanistic...
Aggressive cancers, such as pancreatic ductal adenocarcinoma (PDAC), are often characterized by a complex and desmoplastic tumor microenvironment rich in stroma, supportive connective tissue composed primarily of extracellular matrix (ECM) non-cancerous cells. Desmoplasia, which is dense deposition major reason for therapy resistance, acting both physical barrier that interferes with drug penetration niche protects cancer cells through diverse mechanisms. A precise understanding spatial cell...