A5075515795- Genetics, Bioinformatics, and Biomedical Research
- Machine Learning in Bioinformatics
- Cell Image Analysis Techniques
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Advanced Algorithms and Applications
Zhejiang University
2024
Zhejiang Lab
2024
Beijing University of Chemical Technology
2006
Abstract Mutations in amino acid sequences can provoke changes protein function. Accurate and unsupervised prediction of mutation effects is critical biotechnology biomedicine, but remains a fundamental challenge. To resolve this challenge, here we present Pro tein M utational E ffect P redictor (ProMEP), general multiple sequence alignment-free method that enables zero-shot effects. A multimodal deep representation learning model embedded ProMEP was developed to comprehensively learn both...