A5101886715- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Blood disorders and treatments
- Blood groups and transfusion
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Reproductive tract infections research
- Pancreatitis Pathology and Treatment
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- Animal health and immunology
- Biosimilars and Bioanalytical Methods
- Dermatology and Skin Diseases
- Environmental Science and Water Management
- Nosocomial Infections in ICU
- Retinoids in leukemia and cellular processes
- T-cell and Retrovirus Studies
- Veterinary Orthopedics and Neurology
Hokkaido University
1974-2025
Teikyo University
2018
Hamamatsu University School of Medicine
1999-2015
Chevron (Netherlands)
2010
Sendai Kousei Hospital
2008
Miyagi Prefectural Hospital Organization
2008
Sapporo City General Hospital
2008
Hiroshima University
2002-2008
Ralph H. Johnson VA Medical Center
2000
Medical University of South Carolina
2000
Amrubicin, a new anthracycline agent, and topotecan are both active for previously treated small-cell lung cancer (SCLC). No comparative study of these agents has been reported. This randomized phase II was conducted to select amrubicin or future evaluation.Patients with SCLC platinum-containing chemotherapy were randomly assigned receive (40 mg/m(2) on days 1 through 3) (1.0 5). Patients stratified by Eastern Cooperative Oncology Group performance status (0, 1, 2) type relapse (chemotherapy...
Abstract In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation classical complement pathway with C3 is pathogenic nephritis. Although alternative activated nephritis, its role disease pathogenesis unknown. To determine factor B-deficient mice were backcrossed to MRL/lpr mice. develop a spontaneous lupus-like characterized by complex We derived B wild-type (B+/+), homozygous...
Abstract IgA was purified from chicken bile and intestinal secretions by using Sephadex G-200 gel-filtration DEAE-cellulose chromatography. The molecular structure of biliary in chickens resembled the serum type high polymeric since it lacked a secretory component (SC), had weight 800,000 to 900,000. On other hand, different but quite similar mammalian (SIgA) associated with protein homologous SC value 300,000 500,000. It can be predicted that two types show phylogenically intermediate...
Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule that has an immunosuppressive effect mediated by binding to immune inhibitory immunoglobulin-like receptors (LILR) B1 and LILRB2. A conventional HLA-G isoform, HLA-G1, forms heterotrimeric complex composed of heavy chain (α1-α3 domains), β2-microglobulin (β2m) cognate peptide. One the other isoforms, HLA-G2, lacks α2 domain or β2m form nondisulfide-linked homodimer, its ectodomain specifically binds LILRB2 expressed in...
To clarify the influence of a westernized lifestyle on risk factors for atherosclerosis and preclinical in Japanese subjects, we surveyed population immigrants United States. Based extent westernization their lifestyle, subjects were classified as (J), first generation Japanese-Americans (JA-I), second or later (JA-II). The consumption animal fat simple carbohydrates increased order J, JA-I, JA-II, while with strenuous physical activity decreased same order. waist-hip ratio, fasting insulin...
Oral administration of raffinose, a naturally occurring indigestible oligosaccharide, has reportedly ameliorated atopic dermatitis in human subjects although the mechanism is unknown. The present study investigated effect dietary raffinose on allergen-induced airway eosinophilia ovalbumin-sensitised Brown Norway rats as an disease model. were immunised by subcutaneous injection with ovalbumin day 0 and fed either control diet or supplemented (50 g/kg diet). exposed to aerosolised 20,...
The human leucocyte antigen (HLA)-G, which consists of seven splice variants, is a tolerogenic immune checkpoint molecule. It plays an important role in the protection fetus from maternal response by binding to inhibitory receptors, including leukocyte Ig-like receptors (LILRs). Recent studies have also revealed that HLA-G involved progression cancer cells and autoimmune diseases. In contrast its well characterized isoform, HLA-G1, activities other major isoforms, such as HLA-G2, toward...
Elevation of intracellular Ca 2+ concentration ([Ca ] i ) in endothelial cells is proposed to be required for generation vascular actions endothelium-derived hyperpolarizing factor (EDHF). This study was designed determine the source that important development EDHF-mediated actions. In porcine coronary artery precontracted with U-46619, bradykinin (BK) and cyclopiazonic acid (CPA) caused endothelium-dependent relaxations presence N G -nitro-l-arginine (l-NNA). The l-NNA-resistant relaxant...
Background Chlamydia pneumoniae (Cp) infection has been proposed as a risk factor for coronary artery disease (CAD), but it remains unclear whether Cp plays role in the progression of early stage carotid atherosclerosis. Methods and Results The associations among IgG/IgA antibodies, inflammation markers such C-reactive protein (CRP) interleukin (IL)-6, maximal intima-media wall thickness (max IMT) were evaluated using ultrasonography 259 Japanese Americans. presence IgG or IgA antibodies...
Abstract Background: Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim present study to characterize circulating Gal-9 patients with rheumatoid arthritis (RA) and its relationship RA disease activity phenotype. Methods: A total 116 age-matched healthy controls (n=31) were included this study. Disease determined by Activity Score 28 joint scoring system (DAS28-ESR). Levels serum enzyme-linked immunosorbent assay (ELISA). Results: Serum...
Abstract It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes arsenical carcinogenicity. Here we examined global histone H3 by inorganic arsenite (iAs(III)) and its contribution to gene expression in HeLa cells. iAs(III) induced H3K9 dimethylation (H3K9me2) trimethylation (H3K9me3), H3S10 phosphorylation (H3S10p), H3T11 (H3T11p) H3K9S10 trimethyl‐phosphorylation...
Abstract Background T cell immunoglobulin and mucin domain-3 (TIM-3) is a surface molecules expressed on immune cells which play role in regulation. The aims of the present study were to determine whether circulating soluble (sTIM-3) elevated rheumatoid arthritis (RA) patients, investigate relationships between sTIM-3 clinical features RA. Methods included 116 patients with established RA 27 healthy control subjects. Serum levels measured via enzyme-linked immunosorbent assays (ELISA)....
We investigated the efficacy of infection control measures against nosocomial pneumonia in geriatric wards. Cases with were retrospectively analyzed between January 1991 and March 1995. The study period was divided into four annual periods (periods 1, 2, 3 4). Period to December 1991, applied as cotrol. patients pneumonias wards (190 beds) AINO Memorial Hospital, affiliated Nagasaki University. During period, significantly diminished. (period 1 vs 4, p < 0.05, respectively). Major causative...
In isolated rat mesenteric artery with endothelium, NaF caused slowly developing hyperpolarization. The hyperpolarizing effect was unchanged in the presence of N G ‐nitro‐ L ‐arginine ( ‐NOARG) and indomethacin, but markedly reduced by high K + . Ca 2+ ‐free medium or Ni , failed to produce NaF‐induced hyperpolarization substantially unaffected deferoxamine, an Al 3+ chelator, okadaic acid calyculin A, phosphatase inhibitors, preincubation pertussis toxin, suggesting that neither action...
Abstract Background: The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce inhibitory signaling to regulate immune responses. dysregulated expression checkpoint molecules has been reported under various inflammatory or autoimmune conditions. aim this study is investigate levels these their associations proinflammatory markers in patients with adult Still’s disease (ASD). Methods:...
Abstract BackgroundRheumatoid arthritis (RA) is a heterogeneous inflammatory disease. Both anti-citrullinated peptide antibodies (ACPA) and cytokines play an important role in the development of RA. The aim this study was to investigate association between co-inhibitory checkpoint molecules patients with RA.MethodsOne hundred thirty-two Japanese established RA were enrolled. Serum levels interleukin-6 (IL-6) tumor necrosis factor-α (TNF- α) determined by ELISA. Patients stratified into two...