A5022368551- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Cancer Research and Treatments
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
Georgetown University
2024-2025
Tata Memorial Hospital
2022-2023
Homi Bhabha National Institute
2022-2023
Advanced Centre for Treatment, Research and Education in Cancer
2022-2023
Abstract Precision medicine and genomic profiling with target-specific therapy directed to cancer cell receptors have improved the outcome of many recalcitrant cancers. Strategies deliver gene downregulate driver genes been challenging in vivo. Pancreatic has poorest survival all solid tumors due lack therapies its characteristic tumor microenvironment dense fibrosis abundant immunosuppressive M2-polarized macrophages. In this study, we designed a panel locked nucleic acid (LNA) gapmer...
Abstract Background: Pancreatic cancer has a poor prognosis and novel strategies are needed to improve the survival. Gastrin stimulates growth of pancreatic by an autocrine mechanism RNAi techniques that decrease gastrin expression have been shown inhibit this malignancy in vitro. Locked nucleic acid (LNA) Gapmers antisense oligonucleotides (ASO) long half-life stability vivo, hence represent potential method deliver for therapeutics. We developed LNA Gapmer selectively downregulates cells...